The effect of centrally acting drug chlorpromazine on the secretion of prolactin in the lizard, Uromastix hardwickii. 2003

Mahmood Ahmad, and Ruqaiya Hasan, and Sohail Yameen, and Mansoor Ahmad
Department of Physiology, University of Karachi, Karachi-75270, Pakistan.

This investigation deals with the effect of chlorpromazine, on Uromastix hypophyseal prolactin. Administration of the doses 0.125, 0.25, 0.5 and 1 mg chlorpromazine per 3 days per animal resulted in a significant increase pigeon crop-sac response (p<0.01). The degree of proliferation of crop-gland showed a dose dependent threshold. Chlorpromazine binds to the target cell specific receptors of PRL and GH, both at the same time.

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