-transparent.png){kind=logo}
Elimination and effect on acid secretion of vasoactive intestinal polypeptide (VIP) were studied in six healthy volunteers. On a background infusion of pentagastrin, 100 ng/kg-h, VIP was administered as stepwise intravenous infusions in doses of 0.5, 0.9, and 2.7 micro/g/kg-h, each dose being give for 1 h. Mean plasma VIP concentrations rose from 5.7 pmol/l to 28, 106 and 336 pmol/l during the VIP infusions. No significant changes in acid secretion occurred during VIP infusion as compared to infusion of pentagastrin alone, and no duodeno-gastric reflux was registered. Serum gastrin concentrations were unaltered during VIP infusion. Elimination of VIP was bi-exponential with half-lives of 2 and 21 min, respectively. Metabolic clearance rate was 42 ml/kg-min and the estimated volume of distribution 135 ml/kg.
M Holm-Bentzen, and
J Christiansen, and
B Petersen, and
J Fahrenkrug, and
A Schultz, and
P Kirkegaard
January 1984,
Frontiers of hormone research,
M Holm-Bentzen, and
J Christiansen, and
B Petersen, and
J Fahrenkrug, and
A Schultz, and
P Kirkegaard
May 1991,
Gastroenterology,
M Holm-Bentzen, and
J Christiansen, and
B Petersen, and
J Fahrenkrug, and
A Schultz, and
P Kirkegaard
January 1979,
Scandinavian journal of gastroenterology,
M Holm-Bentzen, and
J Christiansen, and
B Petersen, and
J Fahrenkrug, and
A Schultz, and
P Kirkegaard
April 1982,
Scandinavian journal of gastroenterology,
M Holm-Bentzen, and
J Christiansen, and
B Petersen, and
J Fahrenkrug, and
A Schultz, and
P Kirkegaard
December 1983,
General and comparative endocrinology,
M Holm-Bentzen, and
J Christiansen, and
B Petersen, and
J Fahrenkrug, and
A Schultz, and
P Kirkegaard
February 1980,
Digestive diseases and sciences,
M Holm-Bentzen, and
J Christiansen, and
B Petersen, and
J Fahrenkrug, and
A Schultz, and
P Kirkegaard
October 1983,
Experientia,
M Holm-Bentzen, and
J Christiansen, and
B Petersen, and
J Fahrenkrug, and
A Schultz, and
P Kirkegaard
January 1979,
Scandinavian journal of gastroenterology,
M Holm-Bentzen, and
J Christiansen, and
B Petersen, and
J Fahrenkrug, and
A Schultz, and
P Kirkegaard
January 1980,
Materia medica Polona. Polish journal of medicine and pharmacy,
M Holm-Bentzen, and
J Christiansen, and
B Petersen, and
J Fahrenkrug, and
A Schultz, and
P Kirkegaard
July 1977,
Metabolism: clinical and experimental,
