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In vitro bactericidal activity of human beta-defensin 3 against multidrug-resistant nosocomial strains. 2006
Giuseppantonio Maisetta, and
Giovanna Batoni, and
Semih Esin, and
Walter Florio, and
Daria Bottai, and
Flavia Favilli, and
Mario Campa
Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, University of Pisa, Pisa, Italy.
The antimicrobial activity of human beta-defensin 3 (hBD-3) against multidrug-resistant clinical isolates of Staphylococcus aureus, Enterococcus faecium, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter baumannii was evaluated. A fast bactericidal effect (within 20 min) against all bacterial strains tested was observed. The presence of 20% human serum abolished the bactericidal activity of hBD-3 against gram-negative strains and reduced the activity of the peptide against gram-positive strains.
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