Final height in girls with central idiopathic precocious puberty treated with gonadotropin-releasing hormone analog and oxandrolone. 2006

Alessandra Vottero, and Simona Pedori, and Marta Verna, and Blandina Pagano, and Marco Cappa, and Sandro Loche, and Sergio Bernasconi, and Lucia Ghizzoni
Department of Pediatrics, University of Parma, Via Gramsci 14, 43100 Parma, Italy.

BACKGROUND GnRH analogs (GnRHa) are considered the treatment of choice for central precocious puberty (CPP). During GnRHa administration, the suppression of the pituitary-gonadal axis results in decreased rates of linear growth and skeletal maturation and in improved adult height. However, in some patients, the growth deceleration is so marked that the expected improvement in predicted adult height is not achieved. OBJECTIVE The objective of this study was to assess whether the addition of oxandrolone (Ox) may affect the height outcome of patients with CPP and growth deceleration during GnRHa treatment. METHODS This was an open-label, clinical study. METHODS The study was performed at a pediatric endocrinology referral clinic. METHODS Twenty patients with CPP and marked growth deceleration during GnRHa treatment were studied. METHODS Treatment consisted of GnRHa (Leuprorelina, 3.75 mg im every 28 d) alone (10 patients) or in combination with Ox (0.06 mg/kg.d by mouth) (10 patients). METHODS The main outcome measure was the patients' adult height. RESULTS The adult height of the patients treated with GnRHa plus Ox was significantly higher than pretreatment predicted adult height (162.6 +/- 2.3 vs. 154.8 +/- 1.7 cm, mean +/- sem; P < 0.05) and target height (162.6 +/- 2.3 vs. 158.0 +/- 1.9; P > 0.05). Patients treated with GnRHa alone reached an adult height similar to the pretreatment predicted adult height (151.9 +/- 1.2 vs. 155.4 +/- 2.1 cm) but significantly lower than target height (151.9 +/- 1.2 vs. 156.6 +/- 1.4 cm; P < 0.005). No side effects were recorded in either group of patients. CONCLUSIONS Combined GnRHa and Ox therapy is a viable treatment option for children with CPP and marked growth deceleration during treatment with GnRHa alone.

UI MeSH Term Description Entries
D007334 Insulin-Like Growth Factor I A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor. IGF-I,Somatomedin C,IGF-1,IGF-I-SmC,Insulin Like Growth Factor I,Insulin-Like Somatomedin Peptide I,Insulin Like Somatomedin Peptide I
D007986 Luteinizing Hormone A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity. ICSH (Interstitial Cell Stimulating Hormone),Interstitial Cell-Stimulating Hormone,LH (Luteinizing Hormone),Lutropin,Luteoziman,Luteozyman,Hormone, Interstitial Cell-Stimulating,Hormone, Luteinizing,Interstitial Cell Stimulating Hormone
D010074 Oxandrolone A synthetic hormone with anabolic and androgenic properties. Anavar,Oxandrin,SC-11585,SC 11585,SC11585
D011629 Puberty, Precocious Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE. Familial Precocious Puberty,Idiopathic Sexual Precocity,Precocious Puberty,Precocious Puberty, Central,Precocious Puberty, Male Limited,Precocious Puberty, Male-Limited,Pubertas Praecox,Sexual Precocity,Testotoxicosis,Central Precocious Puberties,Central Precocious Puberty,Familial Precocious Puberties,Idiopathic Sexual Precocities,Male-Limited Precocious Puberties,Male-Limited Precocious Puberty,Praecox, Pubertas,Precocious Puberties,Precocious Puberties, Central,Precocious Puberties, Familial,Precocious Puberties, Male-Limited,Precocious Puberty, Familial,Precocities, Idiopathic Sexual,Precocities, Sexual,Precocity, Idiopathic Sexual,Precocity, Sexual,Puberties, Central Precocious,Puberties, Familial Precocious,Puberties, Male-Limited Precocious,Puberties, Precocious,Puberty, Central Precocious,Puberty, Familial Precocious,Puberty, Male-Limited Precocious,Sexual Precocities,Sexual Precocities, Idiopathic,Sexual Precocity, Idiopathic
D001827 Body Height The distance from the sole to the crown of the head with body standing on a flat surface and fully extended. Body Heights,Height, Body,Heights, Body
D001846 Bone Development The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS. Bone Growth
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D005260 Female Females
D005640 Follicle Stimulating Hormone A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity. FSH (Follicle Stimulating Hormone),Follicle-Stimulating Hormone,Follitropin
D006128 Growth Gradual increase in the number, the size, and the complexity of cells of an individual. Growth generally results in increase in ORGAN WEIGHT; BODY WEIGHT; and BODY HEIGHT.

Related Publications

Alessandra Vottero, and Simona Pedori, and Marta Verna, and Blandina Pagano, and Marco Cappa, and Sandro Loche, and Sergio Bernasconi, and Lucia Ghizzoni
January 2018, PloS one,
Alessandra Vottero, and Simona Pedori, and Marta Verna, and Blandina Pagano, and Marco Cappa, and Sandro Loche, and Sergio Bernasconi, and Lucia Ghizzoni
January 2014, Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,
Alessandra Vottero, and Simona Pedori, and Marta Verna, and Blandina Pagano, and Marco Cappa, and Sandro Loche, and Sergio Bernasconi, and Lucia Ghizzoni
April 2009, Journal of pediatric endocrinology & metabolism : JPEM,
Alessandra Vottero, and Simona Pedori, and Marta Verna, and Blandina Pagano, and Marco Cappa, and Sandro Loche, and Sergio Bernasconi, and Lucia Ghizzoni
January 2015, Hormone research in paediatrics,
Alessandra Vottero, and Simona Pedori, and Marta Verna, and Blandina Pagano, and Marco Cappa, and Sandro Loche, and Sergio Bernasconi, and Lucia Ghizzoni
November 1996, Medicina clinica,
Alessandra Vottero, and Simona Pedori, and Marta Verna, and Blandina Pagano, and Marco Cappa, and Sandro Loche, and Sergio Bernasconi, and Lucia Ghizzoni
May 2009, Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,
Alessandra Vottero, and Simona Pedori, and Marta Verna, and Blandina Pagano, and Marco Cappa, and Sandro Loche, and Sergio Bernasconi, and Lucia Ghizzoni
February 1999, The Journal of clinical endocrinology and metabolism,
Alessandra Vottero, and Simona Pedori, and Marta Verna, and Blandina Pagano, and Marco Cappa, and Sandro Loche, and Sergio Bernasconi, and Lucia Ghizzoni
November 2013, Zhonghua er ke za zhi = Chinese journal of pediatrics,
Alessandra Vottero, and Simona Pedori, and Marta Verna, and Blandina Pagano, and Marco Cappa, and Sandro Loche, and Sergio Bernasconi, and Lucia Ghizzoni
January 2020, Turk pediatri arsivi,
Alessandra Vottero, and Simona Pedori, and Marta Verna, and Blandina Pagano, and Marco Cappa, and Sandro Loche, and Sergio Bernasconi, and Lucia Ghizzoni
March 2023, Annals of pediatric endocrinology & metabolism,
Copied contents to your clipboard!