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Although angiotensin II (AII), a potent vasoconstrictor agent, has been reported to stimulate the hypothalamic-pituitary-adrenal (HPA) axis of laboratory animals, its role in the regulation of this axis in humans appears to be controversial. To examine this question, AII (Val5-AII amide) was infused intravenously into 19 male normal volunteers at the doses of 0, 1, 3.3 and 10 ng/kg/min for 30 min. AII had no effect on plasma ACTH, cortisol, corticotrophin-releasing hormone, arginine vasopressin, and atrial natriuretic factor concentrations, nor did it increase systolic or diastolic arterial blood pressure. On the other hand, AII caused a dose-dependent increase of plasma aldosterone concentrations, suggesting that the doses and the mode of AII infusion were effective. Thus, our data show that peripherally infused AII has no detectable effect on the HPA axis function in humans, at doses capable of stimulating plasma aldosterone secretion, its specific target hormone.
A E Calogero, and
M C Fornito, and
A Aliffi, and
E Vicari, and
M L Moncada, and
F Mantero, and
P Polosa, and
R D'Agata
July 2006,
Clinical endocrinology,
A E Calogero, and
M C Fornito, and
A Aliffi, and
E Vicari, and
M L Moncada, and
F Mantero, and
P Polosa, and
R D'Agata
August 1994,
Respiratory medicine,
A E Calogero, and
M C Fornito, and
A Aliffi, and
E Vicari, and
M L Moncada, and
F Mantero, and
P Polosa, and
R D'Agata
November 1983,
Clinics in endocrinology and metabolism,
A E Calogero, and
M C Fornito, and
A Aliffi, and
E Vicari, and
M L Moncada, and
F Mantero, and
P Polosa, and
R D'Agata
January 1988,
Advances in experimental medicine and biology,
A E Calogero, and
M C Fornito, and
A Aliffi, and
E Vicari, and
M L Moncada, and
F Mantero, and
P Polosa, and
R D'Agata
September 2017,
Expert review of endocrinology & metabolism,
A E Calogero, and
M C Fornito, and
A Aliffi, and
E Vicari, and
M L Moncada, and
F Mantero, and
P Polosa, and
R D'Agata
November 1994,
Annals of the New York Academy of Sciences,
A E Calogero, and
M C Fornito, and
A Aliffi, and
E Vicari, and
M L Moncada, and
F Mantero, and
P Polosa, and
R D'Agata
November 2000,
American journal of obstetrics and gynecology,
A E Calogero, and
M C Fornito, and
A Aliffi, and
E Vicari, and
M L Moncada, and
F Mantero, and
P Polosa, and
R D'Agata
March 2001,
Annals of the New York Academy of Sciences,
A E Calogero, and
M C Fornito, and
A Aliffi, and
E Vicari, and
M L Moncada, and
F Mantero, and
P Polosa, and
R D'Agata
February 1989,
Endocrine reviews,
A E Calogero, and
M C Fornito, and
A Aliffi, and
E Vicari, and
M L Moncada, and
F Mantero, and
P Polosa, and
R D'Agata
March 1970,
British medical journal,
