Social isolation selectively reduces hippocampal brain-derived neurotrophic factor without altering plasma corticosterone. 2006

Sergio Scaccianoce, and Paola Del Bianco, and Giovanna Paolone, and Daniele Caprioli, and Antonella M E Modafferi, and Paolo Nencini, and Aldo Badiani
Department of Human Physiology and Pharmacology, University of Rome "La Sapienza", Italy. sergio.scaccianoce@uniroma1.it

It is well known that housing conditions may alter several physiological and behavioral parameters. In this study, we have investigated whether a prolonged period of partial social isolation can modify central brain-derived neurotrophic (BDNF) concentrations. Male Sprague-Dawley rats were singly housed for 8 weeks before hippocampi, prefrontal cortices and striata were collected for BDNF determination. Compared to rats housed two per cage, isolated rats showed a significant reduction on BDNF protein concentrations in the hippocampus while no changes were observed in the other brain regions examined. Moreover, housing condition had no effect on basal plasma corticosterone. On the basis of the proposed etiological participation of reduced central BDNF concentrations in affective disorders, our results would candidate social isolation as a model for the study of antidepressant treatments.

UI MeSH Term Description Entries
D008297 Male Males
D011863 Radioimmunoassay Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation. Radioimmunoassays
D003345 Corticosterone An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
D004797 Enzyme-Linked Immunosorbent Assay An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed. ELISA,Assay, Enzyme-Linked Immunosorbent,Assays, Enzyme-Linked Immunosorbent,Enzyme Linked Immunosorbent Assay,Enzyme-Linked Immunosorbent Assays,Immunosorbent Assay, Enzyme-Linked,Immunosorbent Assays, Enzyme-Linked
D006624 Hippocampus A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation. Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001522 Behavior, Animal The observable response an animal makes to any situation. Autotomy Animal,Animal Behavior,Animal Behaviors
D012934 Social Isolation The separation of individuals or groups resulting in the lack of or minimizing of social contact and/or communication. This separation may be accomplished by physical separation, by social barriers and by psychological mechanisms. In the latter, there may be interaction but no real communication. Isolation, Social,Social Exclusion,Exclusion, Social,Social Exclusions
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

Sergio Scaccianoce, and Paola Del Bianco, and Giovanna Paolone, and Daniele Caprioli, and Antonella M E Modafferi, and Paolo Nencini, and Aldo Badiani
November 2008, Biological psychiatry,
Sergio Scaccianoce, and Paola Del Bianco, and Giovanna Paolone, and Daniele Caprioli, and Antonella M E Modafferi, and Paolo Nencini, and Aldo Badiani
August 2017, Journal of neuroinflammation,
Sergio Scaccianoce, and Paola Del Bianco, and Giovanna Paolone, and Daniele Caprioli, and Antonella M E Modafferi, and Paolo Nencini, and Aldo Badiani
February 2006, Journal of neuroendocrinology,
Sergio Scaccianoce, and Paola Del Bianco, and Giovanna Paolone, and Daniele Caprioli, and Antonella M E Modafferi, and Paolo Nencini, and Aldo Badiani
March 1998, Experimental neurology,
Sergio Scaccianoce, and Paola Del Bianco, and Giovanna Paolone, and Daniele Caprioli, and Antonella M E Modafferi, and Paolo Nencini, and Aldo Badiani
August 2005, Neuropeptides,
Sergio Scaccianoce, and Paola Del Bianco, and Giovanna Paolone, and Daniele Caprioli, and Antonella M E Modafferi, and Paolo Nencini, and Aldo Badiani
December 2000, Brain research,
Sergio Scaccianoce, and Paola Del Bianco, and Giovanna Paolone, and Daniele Caprioli, and Antonella M E Modafferi, and Paolo Nencini, and Aldo Badiani
July 1999, Journal of neuroscience research,
Sergio Scaccianoce, and Paola Del Bianco, and Giovanna Paolone, and Daniele Caprioli, and Antonella M E Modafferi, and Paolo Nencini, and Aldo Badiani
January 2012, International journal of medical sciences,
Sergio Scaccianoce, and Paola Del Bianco, and Giovanna Paolone, and Daniele Caprioli, and Antonella M E Modafferi, and Paolo Nencini, and Aldo Badiani
January 2002, Neuroscience,
Sergio Scaccianoce, and Paola Del Bianco, and Giovanna Paolone, and Daniele Caprioli, and Antonella M E Modafferi, and Paolo Nencini, and Aldo Badiani
October 2014, Neurobiology of learning and memory,
Copied contents to your clipboard!