T lymphocytes as potential therapeutic drug carrier for cancer treatment. 2006

Ute Steinfeld, and Christine Pauli, and Nikolas Kaltz, and Christian Bergemann, and Hyeck-Hee Lee
Korea Institute of Science and Technology Europe, Universität des Saarlandes, Stuhlsatzenhausweg 97, D-66123 Saarbrücken, Germany. steinfeld@kist-europe.de

The aim of our research is the application of human immune cells (T lymphocytes) as target directed drug carrier. Thereby, the inclusion of therapeutical nanoparticles into immune cells is a new strategy for a localized chemotherapy. The autonomous targeting of diseased sites makes immune cells to perfectly controlled drug delivery systems. The study's aim was to demonstrate the feasibility to mobilise immune cells as therapeutic drug carrier systems which can be combined with existing immunotherapies. Therefore, Jurkat cells as well as T lymphocytes were used to identify the smoothest procedure for loading nanoparticles into immune cells. Different loading processes, incubation times and nanoparticle concentrations were compared. Nanoparticles coated with cytotoxic antibiotic doxorubicin were used in first release experiments. A time dependent liberation of doxorubicin from carrier cells was discussed as first therapeutic approach.

UI MeSH Term Description Entries
D008280 Magnetics The study of MAGNETIC PHENOMENA. Magnetic
D009369 Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D002470 Cell Survival The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D004317 Doxorubicin Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN. Adriamycin,Adriablastin,Adriablastine,Adriblastin,Adriblastina,Adriblastine,Adrimedac,DOXO-cell,Doxolem,Doxorubicin Hexal,Doxorubicin Hydrochloride,Doxorubicin NC,Doxorubicina Ferrer Farm,Doxorubicina Funk,Doxorubicina Tedec,Doxorubicine Baxter,Doxotec,Farmiblastina,Myocet,Onkodox,Ribodoxo,Rubex,Urokit Doxo-cell,DOXO cell,Hydrochloride, Doxorubicin,Urokit Doxo cell
D004337 Drug Carriers Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers. Drug Carrier
D005290 Ferric Compounds Inorganic or organic compounds containing trivalent iron. Compounds, Ferric
D005456 Fluorescent Dyes Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags. Flourescent Agent,Fluorescent Dye,Fluorescent Probe,Fluorescent Probes,Fluorochrome,Fluorochromes,Fluorogenic Substrates,Fluorescence Agents,Fluorescent Agents,Fluorogenic Substrate,Agents, Fluorescence,Agents, Fluorescent,Dyes, Fluorescent,Probes, Fluorescent,Substrates, Fluorogenic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000903 Antibiotics, Antineoplastic Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. Antineoplastic Antibiotics,Cytotoxic Antibiotics,Antibiotics, Cytotoxic
D013601 T-Lymphocytes Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen. T Cell,T Lymphocyte,T-Cells,Thymus-Dependent Lymphocytes,Cell, T,Cells, T,Lymphocyte, T,Lymphocyte, Thymus-Dependent,Lymphocytes, T,Lymphocytes, Thymus-Dependent,T Cells,T Lymphocytes,T-Cell,T-Lymphocyte,Thymus Dependent Lymphocytes,Thymus-Dependent Lymphocyte

Related Publications

Ute Steinfeld, and Christine Pauli, and Nikolas Kaltz, and Christian Bergemann, and Hyeck-Hee Lee
January 2020, Biochemistry,
Ute Steinfeld, and Christine Pauli, and Nikolas Kaltz, and Christian Bergemann, and Hyeck-Hee Lee
June 2018, International journal of molecular sciences,
Ute Steinfeld, and Christine Pauli, and Nikolas Kaltz, and Christian Bergemann, and Hyeck-Hee Lee
January 2015, Expert opinion on therapeutic targets,
Ute Steinfeld, and Christine Pauli, and Nikolas Kaltz, and Christian Bergemann, and Hyeck-Hee Lee
November 2018, IUBMB life,
Ute Steinfeld, and Christine Pauli, and Nikolas Kaltz, and Christian Bergemann, and Hyeck-Hee Lee
November 2012, Respiratory research,
Ute Steinfeld, and Christine Pauli, and Nikolas Kaltz, and Christian Bergemann, and Hyeck-Hee Lee
May 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences,
Ute Steinfeld, and Christine Pauli, and Nikolas Kaltz, and Christian Bergemann, and Hyeck-Hee Lee
February 2007, Drug delivery,
Ute Steinfeld, and Christine Pauli, and Nikolas Kaltz, and Christian Bergemann, and Hyeck-Hee Lee
December 2014, Materials science & engineering. C, Materials for biological applications,
Ute Steinfeld, and Christine Pauli, and Nikolas Kaltz, and Christian Bergemann, and Hyeck-Hee Lee
January 1984, Journal of biological response modifiers,
Ute Steinfeld, and Christine Pauli, and Nikolas Kaltz, and Christian Bergemann, and Hyeck-Hee Lee
November 2012, Lipids in health and disease,
Copied contents to your clipboard!