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1. Dose-response curves for noradrenaline, phenylephrine and clonidine were determined isometrically in 2-mm cylindrical segments from human skin arteries at 24 degrees C and compared to those previously reported at 37 degrees C. 2. Noradrenaline (3 x 10(-10)-3 x 10(-4) M) induced dose-dependent contraction and the sensitivity was increased during cooling. Phentolamine (10(-6) M), prazosin (10(-6) M) or yohimbine (10(-6) M) produced a higher rightward shift of the control curve for noradrenaline during cooling. 3. Phenylephrine (10(-11)-3 x 10(-4) M) and clonidine (10(-11)-10(-6) M) caused dose-dependent contraction and the sensitivity of the arteries was augmented at 24 degrees C. 4. The arteries also showed a lower maximal contraction to the adrenergic agonists used and KCl (50 mM) during cooling. 5. The results suggest that cooling: (a) increases sensitivity of postjunctional alpha 1- and alpha 2-adrenoceptors in human skin arteries and (b) depresses contractility of these arteries to alpha-adrenergic stimulation and direct activation of vascular smooth muscle.
B Gómez, and
J Borbujo, and
A L García-Villalón, and
E Nava-Hernández, and
J Valle, and
J L García, and
G Diéguez
June 2002,
Anesthesia and analgesia,
B Gómez, and
J Borbujo, and
A L García-Villalón, and
E Nava-Hernández, and
J Valle, and
J L García, and
G Diéguez
November 1984,
Acta physiologica Scandinavica,
B Gómez, and
J Borbujo, and
A L García-Villalón, and
E Nava-Hernández, and
J Valle, and
J L García, and
G Diéguez
November 1985,
The American journal of physiology,
B Gómez, and
J Borbujo, and
A L García-Villalón, and
E Nava-Hernández, and
J Valle, and
J L García, and
G Diéguez
July 1986,
The Journal of pharmacology and experimental therapeutics,
B Gómez, and
J Borbujo, and
A L García-Villalón, and
E Nava-Hernández, and
J Valle, and
J L García, and
G Diéguez
August 1988,
Surgery,
B Gómez, and
J Borbujo, and
A L García-Villalón, and
E Nava-Hernández, and
J Valle, and
J L García, and
G Diéguez
January 1988,
Journal of cardiovascular pharmacology,
B Gómez, and
J Borbujo, and
A L García-Villalón, and
E Nava-Hernández, and
J Valle, and
J L García, and
G Diéguez
May 2012,
Journal of applied physiology (Bethesda, Md. : 1985),
B Gómez, and
J Borbujo, and
A L García-Villalón, and
E Nava-Hernández, and
J Valle, and
J L García, and
G Diéguez
February 1992,
The Journal of pharmacology and experimental therapeutics,
B Gómez, and
J Borbujo, and
A L García-Villalón, and
E Nava-Hernández, and
J Valle, and
J L García, and
G Diéguez
January 1993,
Fundamental & clinical pharmacology,
B Gómez, and
J Borbujo, and
A L García-Villalón, and
E Nava-Hernández, and
J Valle, and
J L García, and
G Diéguez
July 1992,
British journal of pharmacology,
