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Systemic clearance of atrial natriuretic peptide (ANP) decreases during postnatal development. To determine the relative contribution of ANP clearance (C) receptors and neutral endopeptidase 24.11 (NEP; EC 3.4.24.11) in regulation of plasma ANP concentration ([ANP]) during maturation, 18- to 60-day-old male Sprague-Dawley rats were anesthetized and infused with rat ANP (35 ng.kg-1.min-1). Infusion of the NEP inhibitor phosphoramidon increased [ANP] and urine guanosine 3',5'-cyclic monophosphate (cGMP) excretion in both weanling and adult rats. Infusion of C-ANP, an analogue that binds C receptors selectively, resulted in a greater rise in [ANP] in preweaned than in adult rats, suggesting a maturational decrease in function of C receptors. Despite the increase in [ANP], however, urine flow, cGMP, and sodium excretion failed to increase in preweaned compared with adult rats. Combined infusion of phosphoramidon and C-ANP resulted in a marked increase in [ANP] and cGMP excretion in weanling and adult rats. These results indicate that both C receptors and NEP modulate plasma [ANP] in the physiological range and that each pathway compensates when the other is inhibited. Age-related differences in the renal response to ANP clearance inhibitors may have important physiological implications in the regulation of sodium balance during development.
R L Chevalier, and
M Garmey, and
R M Scarborough, and
J Linden, and
R A Gomez, and
M J Peach, and
R M Carey
May 1990,
The American journal of physiology,
R L Chevalier, and
M Garmey, and
R M Scarborough, and
J Linden, and
R A Gomez, and
M J Peach, and
R M Carey
March 1991,
The Journal of pharmacology and experimental therapeutics,
R L Chevalier, and
M Garmey, and
R M Scarborough, and
J Linden, and
R A Gomez, and
M J Peach, and
R M Carey
August 1996,
The American journal of physiology,
R L Chevalier, and
M Garmey, and
R M Scarborough, and
J Linden, and
R A Gomez, and
M J Peach, and
R M Carey
July 1990,
The Journal of pharmacology and experimental therapeutics,
R L Chevalier, and
M Garmey, and
R M Scarborough, and
J Linden, and
R A Gomez, and
M J Peach, and
R M Carey
June 1995,
Hypertension research : official journal of the Japanese Society of Hypertension,
R L Chevalier, and
M Garmey, and
R M Scarborough, and
J Linden, and
R A Gomez, and
M J Peach, and
R M Carey
July 1993,
Hypertension (Dallas, Tex. : 1979),
R L Chevalier, and
M Garmey, and
R M Scarborough, and
J Linden, and
R A Gomez, and
M J Peach, and
R M Carey
August 1993,
Hypertension (Dallas, Tex. : 1979),
R L Chevalier, and
M Garmey, and
R M Scarborough, and
J Linden, and
R A Gomez, and
M J Peach, and
R M Carey
December 1991,
The American review of respiratory disease,
R L Chevalier, and
M Garmey, and
R M Scarborough, and
J Linden, and
R A Gomez, and
M J Peach, and
R M Carey
December 1991,
Hypertension (Dallas, Tex. : 1979),
R L Chevalier, and
M Garmey, and
R M Scarborough, and
J Linden, and
R A Gomez, and
M J Peach, and
R M Carey
September 1990,
Hypertension (Dallas, Tex. : 1979),
