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The effects of kappa-opiate agonists on gastrointestinal motility was assessed in Swiss Webster, C57BL/6, BALB/c and DBA/2 strains of mice. The kappa-agonists, PD 117302, U-69593 and U-50488H (3 mg kg-1), were injected subcutaneously and the distance travelled by a charcoal meal in the gastrointestinal tract was measured. All kappa-agonists induced significant inhibition of charcoal meal transit; however, there were significant strain differences in the antitransit effect. It is concluded that kappa-receptors are involved in the inhibition of gastrointestinal transit and that the negative data reported in the literature may be due to a genotype-dependent effect of kappa-agonists.
M Bansinath, and
K Ramabadran, and
H Turndorf, and
M M Puig
December 1982,
European journal of pharmacology,
M Bansinath, and
K Ramabadran, and
H Turndorf, and
M M Puig
January 1999,
European journal of pharmacology,
M Bansinath, and
K Ramabadran, and
H Turndorf, and
M M Puig
February 1983,
The Journal of pharmacology and experimental therapeutics,
M Bansinath, and
K Ramabadran, and
H Turndorf, and
M M Puig
July 1990,
The Journal of pharmacology and experimental therapeutics,
M Bansinath, and
K Ramabadran, and
H Turndorf, and
M M Puig
January 1988,
Life sciences,
M Bansinath, and
K Ramabadran, and
H Turndorf, and
M M Puig
September 1980,
Life sciences,
M Bansinath, and
K Ramabadran, and
H Turndorf, and
M M Puig
February 2001,
Neuroscience letters,
M Bansinath, and
K Ramabadran, and
H Turndorf, and
M M Puig
July 1993,
The Journal of pharmacology and experimental therapeutics,
M Bansinath, and
K Ramabadran, and
H Turndorf, and
M M Puig
May 1988,
European journal of pharmacology,
M Bansinath, and
K Ramabadran, and
H Turndorf, and
M M Puig
May 1991,
Pharmacology, biochemistry, and behavior,
