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omega-Conotoxin GVIA (omega-CT) has been reported to block calcium currents at the L- and N-type calcium channels. In neuronal membranes omega-CT, and the aminoglycoside antibiotic neomycin, have been shown to inhibit [125I]omega-CT binding, presumably acting at the N-type calcium channel. We demonstrate here that the concentration curve for neomycin sulfate inhibition of [125I]omega-CT binding is shifted to the right by GTP analogues or fluoride, increasing the IC50 for neomycin. [125I]omega-CT binding is unaffected by these agents and in competition studies the potency of omega-CT, Ca2+, or La3+ is not modulated by GTP analogues or fluoride. These results indicate that the inhibition of [125I]omega-CT binding by neomycin may be mediated by a GTP binding protein.
R J Stumpo, and
L M Pullan, and
A I Salama
January 1995,
Biochimica et biophysica acta,
R J Stumpo, and
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A I Salama
April 1997,
Biochimica et biophysica acta,
R J Stumpo, and
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A I Salama
March 2000,
Neurochemical research,
R J Stumpo, and
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A I Salama
June 1990,
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R J Stumpo, and
L M Pullan, and
A I Salama
November 1993,
Neurochemical research,
R J Stumpo, and
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A I Salama
September 1993,
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R J Stumpo, and
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A I Salama
November 1987,
Naunyn-Schmiedeberg's archives of pharmacology,
R J Stumpo, and
L M Pullan, and
A I Salama
December 2000,
Neurochemical research,
R J Stumpo, and
L M Pullan, and
A I Salama
October 1993,
Neuroscience letters,
R J Stumpo, and
L M Pullan, and
A I Salama
December 2003,
Neurochemical research,
