BIOMAT Database Logo BIOMAT Database Logo

[The mechanism of airway hyperresponsiveness following immediate bronchial response in ovalbumin (OA)-sensitized guinea pigs]. 1991

K Minoguchi, and H Kobayashi, and K Sunouchi, and H Hoshino, and S Konno, and A Okazawa, and F Kokubu, and S Mita, and M Adachi, and T Takahashi
Department of First Internal Medicine, Showa University School of Medicine.

We have previously demonstrated that airway responsiveness was enhanced following a late bronchial response (LBR) after an allergen challenge in ovalbumin (OA)-sensitized guinea pigs. The purpose of the present studies was to evaluate whether airway responsiveness to methacholine increased after an immediate bronchial response (IBR) and the possible involvement of the beta-adrenoceptor dysfunction in OA-sensitized guinea pigs. Guinea pigs were actively sensitized by aerosolized OA. Following OA exposure, IBR appeared. After IBR when specific airway resistance returned to the base line value, airway responsiveness to methacholine increased significantly. Before OA exposure, propranolol induced bronchoconstriction (PIB) was not provoked, however, after IBR, PIB was provoked and the guinea pigs died because of severe bronchoconstriction. These results suggest that airway responsiveness to methacholine increases significantly after IBR. Furthermore, the dysfunction of the beta-adrenoceptor may be a mechanism of this hyperresponsiveness in OA-sensitized guinea pigs.

UI MeSH Term Description Entries
D008297 Male Males
D010047 Ovalbumin An albumin obtained from the white of eggs. It is a member of the serpin superfamily. Serpin B14
D011943 Receptors, Adrenergic, beta One of two major pharmacologically defined classes of adrenergic receptors. The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS. Adrenergic beta-Receptor,Adrenergic beta-Receptors,Receptors, beta-Adrenergic,beta Adrenergic Receptor,beta-Adrenergic Receptor,beta-Adrenergic Receptors,Receptor, Adrenergic, beta,Adrenergic Receptor, beta,Adrenergic beta Receptor,Adrenergic beta Receptors,Receptor, beta Adrenergic,Receptor, beta-Adrenergic,Receptors, beta Adrenergic,beta Adrenergic Receptors,beta-Receptor, Adrenergic,beta-Receptors, Adrenergic
D001980 Bronchi The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI. Primary Bronchi,Primary Bronchus,Secondary Bronchi,Secondary Bronchus,Tertiary Bronchi,Tertiary Bronchus,Bronchi, Primary,Bronchi, Secondary,Bronchi, Tertiary,Bronchus,Bronchus, Primary,Bronchus, Secondary,Bronchus, Tertiary
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D006168 Guinea Pigs A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research. Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001249 Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). Asthma, Bronchial,Bronchial Asthma,Asthmas
D016084 Bronchoconstriction Narrowing of the caliber of the BRONCHI, physiologically or as a result of pharmacological intervention. Bronchial Constriction,Bronchial Constrictions,Bronchoconstrictions,Constriction, Bronchial,Constrictions, Bronchial
D016210 Methacholine Chloride A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116) Methacholine,2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminium Chloride,Acetyl-2-methylcholine Chloride,Acetyl-beta-methacholine Chloride,Acetyl-beta-methylcholine,Mecholine,Mecholyl,Provocholine,Provokit,Acetyl 2 methylcholine Chloride,Acetyl beta methacholine Chloride,Acetyl beta methylcholine,Chloride, Methacholine

Related Publications

K Minoguchi, and H Kobayashi, and K Sunouchi, and H Hoshino, and S Konno, and A Okazawa, and F Kokubu, and S Mita, and M Adachi, and T Takahashi
Airway hyperresponsiveness to cigarette smoke in ovalbumin-sensitized guinea pigs.
January 2000, American journal of respiratory and critical care medicine,
K Minoguchi, and H Kobayashi, and K Sunouchi, and H Hoshino, and S Konno, and A Okazawa, and F Kokubu, and S Mita, and M Adachi, and T Takahashi
[Bronchial hyperresponsiveness to histamine following antigen challenges in actively sensitized guinea pigs].
May 1991, Arerugi = [Allergy],
K Minoguchi, and H Kobayashi, and K Sunouchi, and H Hoshino, and S Konno, and A Okazawa, and F Kokubu, and S Mita, and M Adachi, and T Takahashi
Effect of baicalin on tracheal permeability in ovalbumin (OA)-sensitized guinea pigs.
October 1999, Pharmaceutical research,
K Minoguchi, and H Kobayashi, and K Sunouchi, and H Hoshino, and S Konno, and A Okazawa, and F Kokubu, and S Mita, and M Adachi, and T Takahashi
Curcumin attenuates allergen-induced airway hyperresponsiveness in sensitized guinea pigs.
July 2003, Biological & pharmaceutical bulletin,
K Minoguchi, and H Kobayashi, and K Sunouchi, and H Hoshino, and S Konno, and A Okazawa, and F Kokubu, and S Mita, and M Adachi, and T Takahashi
Airway hyperreactivity modulated by immunotherapy with denatured ovalbumin in ovalbumin-sensitized guinea pigs.
September 1998, Journal of the Formosan Medical Association = Taiwan yi zhi,
K Minoguchi, and H Kobayashi, and K Sunouchi, and H Hoshino, and S Konno, and A Okazawa, and F Kokubu, and S Mita, and M Adachi, and T Takahashi
Lung surfactant prevents allergic bronchial constriction in ovalbumin sensitized guinea pigs.
January 1985, Biomedica biochimica acta,
K Minoguchi, and H Kobayashi, and K Sunouchi, and H Hoshino, and S Konno, and A Okazawa, and F Kokubu, and S Mita, and M Adachi, and T Takahashi
Bronchial sensitization in guinea pigs following ingestion of ovalbumin.
January 1989, International archives of allergy and applied immunology,
K Minoguchi, and H Kobayashi, and K Sunouchi, and H Hoshino, and S Konno, and A Okazawa, and F Kokubu, and S Mita, and M Adachi, and T Takahashi
Implication of oxygen radicals on airway hyperresponsiveness after ovalbumin challenge in guinea pigs.
March 1992, The American review of respiratory disease,
K Minoguchi, and H Kobayashi, and K Sunouchi, and H Hoshino, and S Konno, and A Okazawa, and F Kokubu, and S Mita, and M Adachi, and T Takahashi
Effect of ascorbic acid on airway responsiveness in ovalbumin sensitized guinea pigs.
December 2003, Respirology (Carlton, Vic.),
K Minoguchi, and H Kobayashi, and K Sunouchi, and H Hoshino, and S Konno, and A Okazawa, and F Kokubu, and S Mita, and M Adachi, and T Takahashi
Antigen-induced airway hyperresponsiveness in absence of broncho-obstruction in sensitized guinea pigs.
April 2013, Experimental lung research,
Copied contents to your clipboard!