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Neurotensin (NT) (12-48 micrograms/kg-1/day-1, for 2 days, s.c.), like ACTH (60 micrograms/kg-1/day-1, for 2 days, s.c.), counteracted the dexamethasone (Dx)-induced (120 micrograms/kg-1/day-1, for 4 days, s.c.) adrenal zona-fasciculata cell atrophy. NT notably raised, in Dx-suppressed rats, the plasma concentration of ACTH, which reached about that found after exogenous ACTH administration. However, at variance with ACTH, NT did not enhance either plasma corticosterone (B) level or B production by adrenal quarters in vitro. The conclusion is drawn that NT modulates the function of the rat pituitary-adrenocortical axis, by simultaneously stimulating hypophyseal ACTH release and inhibiting steroidogenesis at the adrenal level.
L K Malendowicz, and
G G Nussdorfer, and
B Lesniewska, and
A Markowska, and
M Nowak
May 1982,
Acta endocrinologica,
L K Malendowicz, and
G G Nussdorfer, and
B Lesniewska, and
A Markowska, and
M Nowak
May 1984,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
L K Malendowicz, and
G G Nussdorfer, and
B Lesniewska, and
A Markowska, and
M Nowak
March 1978,
Endocrinologia experimentalis,
L K Malendowicz, and
G G Nussdorfer, and
B Lesniewska, and
A Markowska, and
M Nowak
January 1986,
Neuroendocrinology,
L K Malendowicz, and
G G Nussdorfer, and
B Lesniewska, and
A Markowska, and
M Nowak
September 1972,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
L K Malendowicz, and
G G Nussdorfer, and
B Lesniewska, and
A Markowska, and
M Nowak
November 1985,
Clinics in endocrinology and metabolism,
L K Malendowicz, and
G G Nussdorfer, and
B Lesniewska, and
A Markowska, and
M Nowak
December 1995,
Brain research,
L K Malendowicz, and
G G Nussdorfer, and
B Lesniewska, and
A Markowska, and
M Nowak
May 1978,
Physiology & behavior,
L K Malendowicz, and
G G Nussdorfer, and
B Lesniewska, and
A Markowska, and
M Nowak
September 2005,
European journal of pharmacology,
L K Malendowicz, and
G G Nussdorfer, and
B Lesniewska, and
A Markowska, and
M Nowak
August 1973,
Steroids,
