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We studied the Schwann cell (SC) GFAP immunoreactivity in normal human peripheral nerves and in neuropathies of different origin. Immunofluorescence and immunocytochemistry were carried out on serial frozen sections of 58 peripheral nerve biopsies using monoclonal antibodies (mabs) antivimentin and anti GFAP, and antiserum anti S-100 and anti GFAP. To test the specificity of the mabs and antiserum used, proper competition controls on tissue sections of 2 selected cases, tissue cultures studies of human fibroblasts and immunoblotting of homogenates of human fibroblasts, 3 normal and 5 pathologic nerves were carried out. In order to evaluate a possible correlation between SC GFAP positivity and neuropathologic findings a quantitative study was performed, evaluating the SC GFAP reactivity in all the 58 cases, and relating the SC GFAP positivity to the index of nerve pathology (IP) in 9 selected cases, and to the percentage of teased fibers showing axonal degeneration or demyelination and remyelination in 25 representative cases. We demonstrate that in normal human sural nerves and in demyelinating neuropathies only a few scattered SC are recognized by the mabs or antiserum anti GFAP. On the contrary in axonal neuropathies the majority of SC gain the property to express intermediate filaments which show common antigenic properties with GFAP.
G L Mancardi, and
A Cadoni, and
M Tabaton, and
A Schenone, and
A Zicca, and
I De Martini, and
D Bianchini, and
G Damiani, and
D Zaccheo
January 2009,
Advances in experimental medicine and biology,
G L Mancardi, and
A Cadoni, and
M Tabaton, and
A Schenone, and
A Zicca, and
I De Martini, and
D Bianchini, and
G Damiani, and
D Zaccheo
October 1997,
Journal of the neurological sciences,
G L Mancardi, and
A Cadoni, and
M Tabaton, and
A Schenone, and
A Zicca, and
I De Martini, and
D Bianchini, and
G Damiani, and
D Zaccheo
June 2020,
Journal of cell science,
G L Mancardi, and
A Cadoni, and
M Tabaton, and
A Schenone, and
A Zicca, and
I De Martini, and
D Bianchini, and
G Damiani, and
D Zaccheo
July 1969,
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G L Mancardi, and
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M Tabaton, and
A Schenone, and
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D Bianchini, and
G Damiani, and
D Zaccheo
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Brain : a journal of neurology,
G L Mancardi, and
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G Damiani, and
D Zaccheo
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Annals of the New York Academy of Sciences,
G L Mancardi, and
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M Tabaton, and
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G Damiani, and
D Zaccheo
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Annals of the New York Academy of Sciences,
G L Mancardi, and
A Cadoni, and
M Tabaton, and
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A Zicca, and
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D Bianchini, and
G Damiani, and
D Zaccheo
June 2012,
Journal of the neurological sciences,
G L Mancardi, and
A Cadoni, and
M Tabaton, and
A Schenone, and
A Zicca, and
I De Martini, and
D Bianchini, and
G Damiani, and
D Zaccheo
January 1979,
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G L Mancardi, and
A Cadoni, and
M Tabaton, and
A Schenone, and
A Zicca, and
I De Martini, and
D Bianchini, and
G Damiani, and
D Zaccheo
October 2023,
Continuum (Minneapolis, Minn.),
