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Upper airway obstruction by sublingual hematoma: a complication of anticoagulation therapy with acenocoumarol. 2006

Raúl González-García, and Guillermo Schoendorff, and Mario F Muñoz-Guerra, and Francisco J Rodríguez-Campo, and Luis Naval-Gías, and Jesús Sastre-Pérez
Department of Oral and Maxillofacial Surgery, University Hospital La Princesa (Autónoma University), Madrid, Spain. raugg@mixmail.com

Upper airway obstruction secondary to the use of oral anticoagulants has been reported. In most of the cases, it is produced by retropharyngeal and laryngeal hematomas. The sublingual space is an extremely rare site for bleeding, but this constitutes a life-threatening complication, it must be considered as an emergency situation, and the main priority is to secure patient's airway. We recommend immediate reversal of the anticoagulation therapy, preferably with fresh frozen plasma. The surgical drainage usually is not recommended. We present what is to our knowledge the 10th case reported of an airway obstruction due to sublingual hematoma after the administration of oral anticoagulants, and the third one due to the use of acenocoumarol.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009060 Mouth Floor The area of the mouth beneath the TONGUE. Floor of Mouth,Sublingual Region,Floor, Mouth,Floors, Mouth,Mouth Floors,Region, Sublingual,Regions, Sublingual,Sublingual Regions
D011517 Prothrombin Time Clotting time of PLASMA recalcified in the presence of excess TISSUE THROMBOPLASTIN. Factors measured are FIBRINOGEN; PROTHROMBIN; FACTOR V; FACTOR VII; and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS. Quick Test,Russell's Viper Venom Time,Thrombotest,Russell Viper Venom Time,Russells Viper Venom Time,Prothrombin Times,Test, Quick,Time, Prothrombin,Times, Prothrombin
D006406 Hematoma A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue. Hematomas
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000074 Acenocoumarol A coumarin that is used as an anticoagulant. Its actions and uses are similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233) Acenocoumarin,Nicoumalone,Mini-Sintrom,Sinkumar,Sinthrome,Sintrom,Syncoumar,Syncumar,Synthrom,Mini Sintrom,MiniSintrom
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000402 Airway Obstruction Any hindrance to the passage of air into and out of the lungs. Choking,Airway Obstructions,Obstruction, Airway,Obstructions, Airway
D000925 Anticoagulants Agents that prevent BLOOD CLOTTING. Anticoagulant Agent,Anticoagulant Drug,Anticoagulant,Anticoagulant Agents,Anticoagulant Drugs,Anticoagulation Agents,Indirect Thrombin Inhibitors,Agent, Anticoagulant,Agents, Anticoagulant,Agents, Anticoagulation,Drug, Anticoagulant,Drugs, Anticoagulant,Inhibitors, Indirect Thrombin,Thrombin Inhibitors, Indirect

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