-transparent.png){kind=logo}
A case of bronchiolo-alveolar carcinoma (BAC) developing in the presence of idiopathic fibrosing alveolitis (IFA) in a man of 67 with a long history of pulmonary lesion is described. A honeycomb bung was found at the autopsy. Histologically, multiple foci of BAC of mixed-cell structure and those of mucus-producing cells against the background of fibrosing alveolitis at the stage of honeycomb lung were observed. An increased content of collagen type III, IV and V was found immunohistochemically. The role of sclerotic changes and defected immunological surveillance over the epithelial regeneration in the IFA-affected lung in relevant carcinoma genesis is suggested. The origin of the lung carcinoma in IFA is considered to be the regenerating epithelium of the low respiratory tract.
E A Kogan, and
B M Kornev, and
R A Shukurova
September 1977,
Fortschritte der Medizin,
E A Kogan, and
B M Kornev, and
R A Shukurova
August 1984,
Problemy tuberkuleza,
E A Kogan, and
B M Kornev, and
R A Shukurova
October 1990,
Vrachebnoe delo,
E A Kogan, and
B M Kornev, and
R A Shukurova
November 1981,
Orvosi hetilap,
E A Kogan, and
B M Kornev, and
R A Shukurova
May 1985,
European journal of respiratory diseases,
E A Kogan, and
B M Kornev, and
R A Shukurova
January 1984,
Arkhiv patologii,
E A Kogan, and
B M Kornev, and
R A Shukurova
October 1965,
British journal of diseases of the chest,
E A Kogan, and
B M Kornev, and
R A Shukurova
January 2005,
Klinicheskaia meditsina,
E A Kogan, and
B M Kornev, and
R A Shukurova
September 2003,
Clinical and experimental medicine,
E A Kogan, and
B M Kornev, and
R A Shukurova
May 1990,
Klinicheskaia meditsina,
