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Stimulation of polymorphonuclear leukocytes with kallikrein demonstrated that enzyme acts selectively on the release of lysosomal enzymes of these cells. The release of collagenase, similarly to the release of lysozyme into the incubation medium increased proportionally to kallikrein concentration and the duration of incubation. Kallikrein had a small effect on beta-glucuronidase secretion. No effect on cytoplasm lactate dehydrogenase release was detected. These results suggest that kallikrein, as a soluble stimulus, predominantly induces degranulation of specific granules containing collagenase capable of degrading the connective tissue. Secretion of lysozyme and collagenase requires the presence of active kallikrein. Soybean trypsin inhibitor diminished the enzyme release.
M Stancíková, and
M Rybák, and
K Simonianová, and
M Ondrsik
January 1982,
Zeitschrift fur Rheumatologie,
M Stancíková, and
M Rybák, and
K Simonianová, and
M Ondrsik
September 1975,
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M Stancíková, and
M Rybák, and
K Simonianová, and
M Ondrsik
June 1987,
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M Stancíková, and
M Rybák, and
K Simonianová, and
M Ondrsik
December 1984,
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M Stancíková, and
M Rybák, and
K Simonianová, and
M Ondrsik
September 1977,
Journal of endodontics,
M Stancíková, and
M Rybák, and
K Simonianová, and
M Ondrsik
September 1982,
Arerugi = [Allergy],
M Stancíková, and
M Rybák, and
K Simonianová, and
M Ondrsik
March 1973,
Proceedings of the National Academy of Sciences of the United States of America,
M Stancíková, and
M Rybák, and
K Simonianová, and
M Ondrsik
September 1975,
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M Stancíková, and
M Rybák, and
K Simonianová, and
M Ondrsik
February 1984,
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M Stancíková, and
M Rybák, and
K Simonianová, and
M Ondrsik
January 1983,
Advances in experimental medicine and biology,
