BIOMAT Database Logo BIOMAT Database Logo

Sensitive line probe assay that simultaneously detects mutations conveying resistance to lamivudine and adefovir. 2006

Munira Hussain, and Scott Fung, and Evelien Libbrecht, and Erwin Sablon, and Carmela Cursaro, and Pietro Andreone, and Anna S F Lok
Division of Gastroenterology, University of Michigan Medical Center, 1500 East Medical Center Drive, 3912 Taubman Center, Box 0362, Ann Arbor, Michigan 48109-0362, USA.

The INNO-LiPA HBV DR v2 assay is designed to detect hepatitis B virus mutations conveying resistance to lamivudine and adefovir. Our study confirms that this assay can simultaneously detect the presence of lamivudine and adefovir resistance mutations in clinical samples, has a high degree of concordance with sequencing, and can detect mutants earlier.

UI MeSH Term Description Entries
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D004279 DNA, Viral Deoxyribonucleic acid that makes up the genetic material of viruses. Viral DNA
D005814 Genes, Viral The functional hereditary units of VIRUSES. Viral Genes,Gene, Viral,Viral Gene
D006515 Hepatitis B virus The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum. Dane Particle,Hepatitis Virus, Homologous Serum,B virus, Hepatitis,Hepatitis B viruses,Particle, Dane,viruses, Hepatitis B
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000225 Adenine A purine base and a fundamental unit of ADENINE NUCLEOTIDES. Vitamin B 4,4, Vitamin B,B 4, Vitamin
D000998 Antiviral Agents Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. Antiviral,Antiviral Agent,Antiviral Drug,Antivirals,Antiviral Drugs,Agent, Antiviral,Agents, Antiviral,Drug, Antiviral,Drugs, Antiviral
D001483 Base Sequence The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence. DNA Sequence,Nucleotide Sequence,RNA Sequence,DNA Sequences,Base Sequences,Nucleotide Sequences,RNA Sequences,Sequence, Base,Sequence, DNA,Sequence, Nucleotide,Sequence, RNA,Sequences, Base,Sequences, DNA,Sequences, Nucleotide,Sequences, RNA
D012194 RNA-Directed DNA Polymerase An enzyme that synthesizes DNA on an RNA template. It is encoded by the pol gene of retroviruses and by certain retrovirus-like elements. EC 2.7.7.49. DNA Polymerase, RNA-Directed,RNA-Dependent DNA Polymerase,Reverse Transcriptase,RNA Transcriptase,Revertase,DNA Polymerase, RNA Directed,DNA Polymerase, RNA-Dependent,RNA Dependent DNA Polymerase,RNA Directed DNA Polymerase
D012680 Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) Specificity,Sensitivity,Specificity and Sensitivity

Related Publications

Munira Hussain, and Scott Fung, and Evelien Libbrecht, and Erwin Sablon, and Carmela Cursaro, and Pietro Andreone, and Anna S F Lok
De novo entecavir+adefovir dipivoxil+lamivudine triple-resistance mutations resulting from sequential therapy with adefovir dipivoxil, and lamivudine.
April 2016, Annals of clinical microbiology and antimicrobials,
Munira Hussain, and Scott Fung, and Evelien Libbrecht, and Erwin Sablon, and Carmela Cursaro, and Pietro Andreone, and Anna S F Lok
Genotyping hepatitis C viruses from Southeast Asia by a novel line probe assay that simultaneously detects core and 5' untranslated regions.
November 2006, Journal of clinical microbiology,
Munira Hussain, and Scott Fung, and Evelien Libbrecht, and Erwin Sablon, and Carmela Cursaro, and Pietro Andreone, and Anna S F Lok
Combination adefovir-lamivudine prevents emergence of adefovir resistance in lamivudine-resistant hepatitis B.
September 2007, Journal of gastroenterology and hepatology,
Munira Hussain, and Scott Fung, and Evelien Libbrecht, and Erwin Sablon, and Carmela Cursaro, and Pietro Andreone, and Anna S F Lok
An artificial nucleoside that simultaneously detects and combats drug resistance to doxorubicin.
February 2020, European journal of haematology,
Munira Hussain, and Scott Fung, and Evelien Libbrecht, and Erwin Sablon, and Carmela Cursaro, and Pietro Andreone, and Anna S F Lok
Evolution of primary and compensatory lamivudine resistance mutations in chronic hepatitis B virus-infected patients during long-term lamivudine treatment, assessed by a line probe assay.
December 2007, Journal of clinical microbiology,
Munira Hussain, and Scott Fung, and Evelien Libbrecht, and Erwin Sablon, and Carmela Cursaro, and Pietro Andreone, and Anna S F Lok
[Antiviral efficacy of lamivudine/adefovir combination therapy in chronic hepatitis b patients with resistance to lamivudine and adefovir consecutively].
May 2009, The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi,
Munira Hussain, and Scott Fung, and Evelien Libbrecht, and Erwin Sablon, and Carmela Cursaro, and Pietro Andreone, and Anna S F Lok
Susceptibility to antivirals of a human HBV strain with mutations conferring resistance to both lamivudine and adefovir.
June 2005, Hepatology (Baltimore, Md.),
Munira Hussain, and Scott Fung, and Evelien Libbrecht, and Erwin Sablon, and Carmela Cursaro, and Pietro Andreone, and Anna S F Lok
Antiviral efficacy of adefovir dipivoxil versus lamivudine in patients with chronic hepatitis B sequentially treated with lamivudine and adefovir due to lamivudine resistance.
August 2007, World journal of gastroenterology,
Munira Hussain, and Scott Fung, and Evelien Libbrecht, and Erwin Sablon, and Carmela Cursaro, and Pietro Andreone, and Anna S F Lok
Mutations in hepatitis B DNA polymerase associated with resistance to lamivudine do not confer resistance to adefovir in vitro.
December 1998, Hepatology (Baltimore, Md.),
Munira Hussain, and Scott Fung, and Evelien Libbrecht, and Erwin Sablon, and Carmela Cursaro, and Pietro Andreone, and Anna S F Lok
Resistance to adefovir dipivoxil in lamivudine resistant chronic hepatitis B patients treated with adefovir dipivoxil.
October 2006, Gut,
Copied contents to your clipboard!