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The responses to mechanical loading of two types of osteoblast-like cells and skin fibroblasts were investigated using two new devices for applying defined and homogeneous strains to cells. The results indicate that only periostal (bone surface) osteoblasts are sensitive to strains within the physiological range and that a specific strain mechanism is responsible. Osteoblasts derived from the haversian system and skin fibroblasts do not respond except at higher, unphysiological strains. The mechanism is located in the cytoskeleton and activates the membrane phospholipase C within milliseconds and may react to distension of a strain sensitive protein. Activation of phospholipase C can account for only some of the observed responses of bone to mechanical loading such as stimulation of cell division, increase in collagen and collagenase production. Application of over 10,000 mu strains results in a de-differentiation of the osteoblasts and a change in cell morphology to become fibroblast-like.
D B Jones, and
H Nolte, and
J G Scholübbers, and
E Turner, and
D Veltel
May 2003,
Current opinion in clinical nutrition and metabolic care,
D B Jones, and
H Nolte, and
J G Scholübbers, and
E Turner, and
D Veltel
May 1995,
The American journal of physiology,
D B Jones, and
H Nolte, and
J G Scholübbers, and
E Turner, and
D Veltel
October 2000,
Molecular and cellular endocrinology,
D B Jones, and
H Nolte, and
J G Scholübbers, and
E Turner, and
D Veltel
October 1999,
The American journal of physiology,
D B Jones, and
H Nolte, and
J G Scholübbers, and
E Turner, and
D Veltel
June 2016,
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih,
D B Jones, and
H Nolte, and
J G Scholübbers, and
E Turner, and
D Veltel
October 1999,
Bone,
D B Jones, and
H Nolte, and
J G Scholübbers, and
E Turner, and
D Veltel
June 2018,
Cancers,
D B Jones, and
H Nolte, and
J G Scholübbers, and
E Turner, and
D Veltel
January 2009,
Methods in molecular biology (Clifton, N.J.),
D B Jones, and
H Nolte, and
J G Scholübbers, and
E Turner, and
D Veltel
June 2004,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
D B Jones, and
H Nolte, and
J G Scholübbers, and
E Turner, and
D Veltel
January 2003,
The Journal of bone and joint surgery. American volume,
