-transparent.png){kind=logo}
1. The effects of renin inhibitor ES-8891 on renin synthesis and its secretion by the kidney were investigated in normotensive sodium-depleted marmosets. We measured plasma renin activity, plasma immunoreactive renin concentration, plasma angiotensin II concentration and kidney renin mRNA content after oral administration of ES-8891 (60 mg day-1 kg-1) for 1 week. 2. The mean blood pressure was significantly decreased (P less than 0.01) on day 7 after oral administration of ES-8891. There was no significant change in heart rate during the administration. 3. Oral administration of ES-8891 for 1 week markedly decreased the plasma renin activity, the plasma immunoreactive renin concentration and the plasma angiotensin II concentration (to 18%, 41% and 24% of the corresponding control values; P less than 0.05 for each, n = 5). 4. The kidney renin mRNA content in ES-8891-treated marmosets was significantly lower than that in normal controls (4.2 +/- 3.5 versus 12.8 +/- 5.5 pg/micrograms of total RNA, means +/- SD, P less than 0.05, n = 5). 5. Oral administration of the renin inhibitor ES-8891 for 1 week not only inhibited plasma renin activity but also decreased renin synthesis and its secretion by the kidney.
Y Kitami, and
K Hiwada, and
E Murakami, and
T Iwata, and
S Muneta, and
T Kokubu
November 1986,
The American journal of physiology,
Y Kitami, and
K Hiwada, and
E Murakami, and
T Iwata, and
S Muneta, and
T Kokubu
January 1983,
Clinical and experimental hypertension. Part A, Theory and practice,
Y Kitami, and
K Hiwada, and
E Murakami, and
T Iwata, and
S Muneta, and
T Kokubu
December 1989,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
Y Kitami, and
K Hiwada, and
E Murakami, and
T Iwata, and
S Muneta, and
T Kokubu
July 1987,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
Y Kitami, and
K Hiwada, and
E Murakami, and
T Iwata, and
S Muneta, and
T Kokubu
January 1998,
Journal of hypertension,
Y Kitami, and
K Hiwada, and
E Murakami, and
T Iwata, and
S Muneta, and
T Kokubu
October 2009,
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir,
Y Kitami, and
K Hiwada, and
E Murakami, and
T Iwata, and
S Muneta, and
T Kokubu
April 1988,
The American journal of physiology,
Y Kitami, and
K Hiwada, and
E Murakami, and
T Iwata, and
S Muneta, and
T Kokubu
January 1987,
Clinical and experimental hypertension. Part A, Theory and practice,
Y Kitami, and
K Hiwada, and
E Murakami, and
T Iwata, and
S Muneta, and
T Kokubu
December 2008,
Kidney international,
Y Kitami, and
K Hiwada, and
E Murakami, and
T Iwata, and
S Muneta, and
T Kokubu
September 1995,
Mechanisms of ageing and development,
