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Development of activity-based probes for trypsin-family serine proteases. 2006
Zhengying Pan, and
Douglas A Jeffery, and
Kareem Chehade, and
Jerlyn Beltman, and
James M Clark, and
Paul Grothaus, and
Matthew Bogyo, and
Amos Baruch
Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA. zypan@yahoo.com
A series of diphenylphosphonate-based probes were developed for the trypsin-like serine proteases. These probes selectively target serine proteases rather than general serine hydrolases that are targets for fluorophosphonate-based probes. This increased selectivity allows detection of low abundance serine proteases in complex proteomes using simple SDS-PAGE methods. We present here the application of multiple probes in enzyme activity profiling of intact mast cells, a type of inflammatory cell implicated in allergy and autoimmune diseases.
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