Consistent evidence has shown a positive association between particulate matter with an aerodiameter of less than or equal to 10 mum (PM(10)) and daily mortality. Less is known about the modification of this association by factors measured at the individual level. The authors examined this question in a case-crossover study of 20 US cities. Mortality events (1.9 million) were obtained for nonaccidental, respiratory, heart disease, and stroke mortality between 1989 and 2000. PM(10) concentrations were obtained from the US Environmental Protection Agency. The authors examined the modification of the PM(10)-mortality association by sociodemographics, location of death, season, and secondary diagnoses. They found different patterns of PM(10)-mortality associations by gender and age but no differences by race. The level of education was inversely related to the risk of mortality associated with PM(10). PM(10)-related, out-of-hospital deaths were more likely than were in-hospital deaths, as were those occurring during spring/fall versus summer/winter. A secondary diagnosis of diabetes modified the effect of PM(10) for respiratory and stroke mortality. Pneumonia was a positive effect modifier for deaths from all causes and stroke, while secondary stroke modified the effects for all-cause and respiratory deaths. The findings suggest that more attention must be paid to population characteristics to identify greater likelihood of exposures and susceptibility and, as a result, to improve policy making for air pollution standards.