-transparent.png){kind=logo}
Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine. 2006
Dmitriy Alexeev, and
Robert L Baxter, and
Dominic J Campopiano, and
Olivier Kerbarh, and
Lindsay Sawyer, and
Nicholas Tomczyk, and
Rory Watt, and
Scott P Webster
School of Biology, Swann Building, University of Edinburgh, Mayfield Road, Edinburgh, UKEH9 3JR.
The irreversible inhibition of 8-amino-7-oxononanoate synthase by trifluoroalanine involves decarboxylative defluorination of the inhibitor-PLP aldimine followed by attack of the conjugated imine by the amino group of the active site lysine to afford a covalently bound difluorinated intermediate which can subsequently undergo further HF losses and hydrolysis to afford a 2-(pyridoximine phosphate) acetoyl protein adduct.
Related Publications
Dmitriy Alexeev, and
Robert L Baxter, and
Dominic J Campopiano, and
Olivier Kerbarh, and
Lindsay Sawyer, and
Nicholas Tomczyk, and
Rory Watt, and
Scott P Webster
January 2006,
Chemical communications (Cambridge, England),
Dmitriy Alexeev, and
Robert L Baxter, and
Dominic J Campopiano, and
Olivier Kerbarh, and
Lindsay Sawyer, and
Nicholas Tomczyk, and
Rory Watt, and
Scott P Webster
November 2015,
Pesticide biochemistry and physiology,
Dmitriy Alexeev, and
Robert L Baxter, and
Dominic J Campopiano, and
Olivier Kerbarh, and
Lindsay Sawyer, and
Nicholas Tomczyk, and
Rory Watt, and
Scott P Webster
July 2011,
Archives of biochemistry and biophysics,
Dmitriy Alexeev, and
Robert L Baxter, and
Dominic J Campopiano, and
Olivier Kerbarh, and
Lindsay Sawyer, and
Nicholas Tomczyk, and
Rory Watt, and
Scott P Webster
January 1994,
Biochemical and biophysical research communications,
Dmitriy Alexeev, and
Robert L Baxter, and
Dominic J Campopiano, and
Olivier Kerbarh, and
Lindsay Sawyer, and
Nicholas Tomczyk, and
Rory Watt, and
Scott P Webster
January 2018,
Applied and environmental microbiology,
Dmitriy Alexeev, and
Robert L Baxter, and
Dominic J Campopiano, and
Olivier Kerbarh, and
Lindsay Sawyer, and
Nicholas Tomczyk, and
Rory Watt, and
Scott P Webster
February 1975,
Journal of medicinal chemistry,
Dmitriy Alexeev, and
Robert L Baxter, and
Dominic J Campopiano, and
Olivier Kerbarh, and
Lindsay Sawyer, and
Nicholas Tomczyk, and
Rory Watt, and
Scott P Webster
October 1980,
Archives of biochemistry and biophysics,
Dmitriy Alexeev, and
Robert L Baxter, and
Dominic J Campopiano, and
Olivier Kerbarh, and
Lindsay Sawyer, and
Nicholas Tomczyk, and
Rory Watt, and
Scott P Webster
February 2007,
Journal of biomolecular structure & dynamics,
Dmitriy Alexeev, and
Robert L Baxter, and
Dominic J Campopiano, and
Olivier Kerbarh, and
Lindsay Sawyer, and
Nicholas Tomczyk, and
Rory Watt, and
Scott P Webster
July 1996,
Acta crystallographica. Section D, Biological crystallography,
Dmitriy Alexeev, and
Robert L Baxter, and
Dominic J Campopiano, and
Olivier Kerbarh, and
Lindsay Sawyer, and
Nicholas Tomczyk, and
Rory Watt, and
Scott P Webster
May 1990,
Analytical biochemistry,
