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The metabolism of 4- 14-C-progesterone was studied in two adult female chimpanzees (Pan troglodytes). After intravenous injection of 4- 14-C-progesterone, urine was collected for 5 days. The urinary conjugates were hydrolyzed with Glusulase and the extracts purified by chromatography on silica gel, paper and alumina and then crystallized to constant specific activity with or without carrier steroid. The major metabolite in both experiments was pregnanediol which accounted for 39.8% and 49.5% of the recovered dose respectively. Pregnanolone (0.6% and 2.1%) and pregnanetriol (0.1% and 1.5%) were also isolated in smaller quantities. These data suggest that the pattern of progesterone metabolism in the chimpanzee is similar to that of man in that pregnanediol is the major metabolite whereas androsterone is not.
E V YoungLai, and
C E Graham, and
D C Collins
May 1972,
Steroids,
E V YoungLai, and
C E Graham, and
D C Collins
September 1971,
Endocrinology,
E V YoungLai, and
C E Graham, and
D C Collins
May 1972,
Acta endocrinologica,
E V YoungLai, and
C E Graham, and
D C Collins
February 1967,
Revue francaise d'etudes cliniques et biologiques,
E V YoungLai, and
C E Graham, and
D C Collins
June 1967,
Folia endocrinologica,
E V YoungLai, and
C E Graham, and
D C Collins
July 1961,
Acta endocrinologica,
E V YoungLai, and
C E Graham, and
D C Collins
August 1968,
Life sciences,
E V YoungLai, and
C E Graham, and
D C Collins
October 1972,
General and comparative endocrinology,
E V YoungLai, and
C E Graham, and
D C Collins
December 1971,
The Journal of endocrinology,
E V YoungLai, and
C E Graham, and
D C Collins
February 1973,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
