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The intracardiac hemodynamics was studied in 33 patients with exertional angina pectoris undergoing an acute drug test with verapamil (n-15) and nifedipine (n-18) by using radionuclide ventriculography both at rest and during exercise. All the patients were divided into 2 groups by the increase in exercise duration with the two drugs: 1) those who exhibited a marked antianginal effect and 2) those without it. At rest, the calcium antagonists enhanced ejection fraction in the two groups. Exercise ejection fraction also increased, but in a subgroup of patients who displayed no higher exercise tolerance with verapamil. Verapamil and nifedipine in Group 1 patients resulted in lower left ventricular end diastolic volume. It is suggested that the antianginal effect of calcium antagonists is to a certain degree associated with decreased afterload, as manifested by diminished left ventricular end systolic volume.
F I Zeĭnalov, and
A G Malov, and
N A Mazur, and
V B Sergienko, and
A B Sumarokov, and
A I Rubanovich
October 1996,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
F I Zeĭnalov, and
A G Malov, and
N A Mazur, and
V B Sergienko, and
A B Sumarokov, and
A I Rubanovich
October 1990,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
F I Zeĭnalov, and
A G Malov, and
N A Mazur, and
V B Sergienko, and
A B Sumarokov, and
A I Rubanovich
November 1985,
The American journal of physiology,
F I Zeĭnalov, and
A G Malov, and
N A Mazur, and
V B Sergienko, and
A B Sumarokov, and
A I Rubanovich
June 1996,
Kidney international. Supplement,
F I Zeĭnalov, and
A G Malov, and
N A Mazur, and
V B Sergienko, and
A B Sumarokov, and
A I Rubanovich
May 1992,
Kidney international. Supplement,
F I Zeĭnalov, and
A G Malov, and
N A Mazur, and
V B Sergienko, and
A B Sumarokov, and
A I Rubanovich
March 1993,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
F I Zeĭnalov, and
A G Malov, and
N A Mazur, and
V B Sergienko, and
A B Sumarokov, and
A I Rubanovich
January 1989,
Zeitschrift fur Kardiologie,
F I Zeĭnalov, and
A G Malov, and
N A Mazur, and
V B Sergienko, and
A B Sumarokov, and
A I Rubanovich
September 1987,
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics,
F I Zeĭnalov, and
A G Malov, and
N A Mazur, and
V B Sergienko, and
A B Sumarokov, and
A I Rubanovich
January 1998,
Cardiology,
F I Zeĭnalov, and
A G Malov, and
N A Mazur, and
V B Sergienko, and
A B Sumarokov, and
A I Rubanovich
August 1989,
Nihon rinsho. Japanese journal of clinical medicine,
