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To determine the importance of airway inflammation for exacerbation and prognosis of asthma induced by toluene diisocyanate (TDI), we first examined sensitized subjects during asthmatic reactions induced by exposure to TDI in the laboratory. We observed that late and dual, but not early, asthmatic reactions induced by TDI are accompanied by a transient increase of airway responsiveness, bronchoalveolar neutrophilia followed by eosinophilia and by an increase of LTB4 and albumin in bronchoalveolar lavage fluid. All these effects were prevented by pretreatment with prednisone. In addition, we examined the lung pathology of 1 sensitized subject who died after exposure at work. The pathologic features of fatal asthma induced by TDI and of chronic asthma induced by TDI suggest the importance of inflammation for the exacerbation and prognosis of the disease.
L M Fabbri, and
M Saetta, and
G Picotti, and
C E Mapp
September 1987,
The Journal of allergy and clinical immunology,
L M Fabbri, and
M Saetta, and
G Picotti, and
C E Mapp
January 1987,
Advances in prostaglandin, thromboxane, and leukotriene research,
L M Fabbri, and
M Saetta, and
G Picotti, and
C E Mapp
April 1991,
The European respiratory journal. Supplement,
L M Fabbri, and
M Saetta, and
G Picotti, and
C E Mapp
November 1985,
The American review of respiratory disease,
L M Fabbri, and
M Saetta, and
G Picotti, and
C E Mapp
May 1985,
The Journal of allergy and clinical immunology,
L M Fabbri, and
M Saetta, and
G Picotti, and
C E Mapp
December 1987,
The American review of respiratory disease,
L M Fabbri, and
M Saetta, and
G Picotti, and
C E Mapp
October 1989,
Annals of allergy,
L M Fabbri, and
M Saetta, and
G Picotti, and
C E Mapp
May 1992,
European journal of pharmacology,
L M Fabbri, and
M Saetta, and
G Picotti, and
C E Mapp
November 1987,
The American review of respiratory disease,
L M Fabbri, and
M Saetta, and
G Picotti, and
C E Mapp
January 1990,
Lung,
