BIOMAT Database Logo BIOMAT Database Logo

Virus antibody levels in serum specimens from patients with optic neuritis and from matched controls;. 1975

E Nikoskelainen, and J Nikoskelainen, and A A Salmi, and P E Halonen

Virus antibody levels in serum specimens taken in acute and convalescent phases from 77 patients with optic neuritits were tested by measles hamagglutination inhibition (HI), measles hemolysis inhibition (HLI), rubella HI, parainfluenza-1 HI, Epstein-Barr immunofluorescence (IF), and against 11 other viruses and mycoplasma pneumoniae with the complement fixation (CF) technique. The virus antibody levels were indicated to be usually very stable, and a fourfold change in virus antibody levels was demonstrated in only eight patients. The virus antibody levels were compared with specimens from two carefully selected control groups. The first control group consisted of 71 healthy persons matched in age, sex and place of residence with the patients with optic neuritis. The other control group consisted of 58 patients with various neurological diseases other than multiple sclerosis (MS) or infectious diseases of the central nervous system. The patients with optic neuritis had significantly higher measles antibody titres than the two control groups in both measles HI and measles HLI tests. Also in 33 patients with optic neuritis of unknown cause, the measles antibody levels were higher than in the control groups. On the other hand, various other antibody tests showed no statistically significant differences between patients with optic neuritis and the control group.

UI MeSH Term Description Entries
D008297 Male Males
D008459 Measles virus The type species of MORBILLIVIRUS and the cause of the highly infectious human disease MEASLES, which affects mostly children. Edmonston virus
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009103 Multiple Sclerosis An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903) MS (Multiple Sclerosis),Multiple Sclerosis, Acute Fulminating,Sclerosis, Disseminated,Disseminated Sclerosis,Sclerosis, Multiple
D009902 Optic Neuritis Inflammation of the optic nerve. Commonly associated conditions include autoimmune disorders such as MULTIPLE SCLEROSIS, infections, and granulomatous diseases. Clinical features include retro-orbital pain that is aggravated by eye movement, loss of color vision, and contrast sensitivity that may progress to severe visual loss, an afferent pupillary defect (Marcus-Gunn pupil), and in some instances optic disc hyperemia and swelling. Inflammation may occur in the portion of the nerve within the globe (neuropapillitis or anterior optic neuritis) or the portion behind the globe (retrobulbar neuritis or posterior optic neuritis). Neuropapillitis,Retrobulbar Neuritis,Anterior Optic Neuritis,Posterior Optic Neuritis,Anterior Optic Neuritides,Neuritides, Anterior Optic,Neuritides, Optic,Neuritides, Posterior Optic,Neuritides, Retrobulbar,Neuritis, Anterior Optic,Neuritis, Optic,Neuritis, Posterior Optic,Neuritis, Retrobulbar,Neuropapillitides,Optic Neuritides,Optic Neuritides, Anterior,Optic Neuritides, Posterior,Optic Neuritis, Anterior,Optic Neuritis, Posterior,Posterior Optic Neuritides,Retrobulbar Neuritides
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D004854 Herpesvirus 4, Human The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies. Burkitt Herpesvirus,Burkitt Lymphoma Virus,E-B Virus,EBV,Epstein-Barr Virus,Human Herpesvirus 4,Infectious Mononucleosis Virus,Burkitt's Lymphoma Virus,HHV-4,Herpesvirus 4 (gamma), Human,Burkitts Lymphoma Virus,E B Virus,E-B Viruses,Epstein Barr Virus,Herpesvirus, Burkitt,Infectious Mononucleosis Viruses,Lymphoma Virus, Burkitt,Mononucleosis Virus, Infectious,Mononucleosis Viruses, Infectious
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000208 Acute Disease Disease having a short and relatively severe course. Acute Diseases,Disease, Acute,Diseases, Acute

Related Publications

E Nikoskelainen, and J Nikoskelainen, and A A Salmi, and P E Halonen
Virus antibodies in serum specimens from patients with multiple sclerosis, from siblings, and matched controls. A final report.
January 1973, Acta neurologica Scandinavica,
E Nikoskelainen, and J Nikoskelainen, and A A Salmi, and P E Halonen
Serum antibody levels to glycosylphosphatidylinositols in specimens derived from matched Malian children with severe or uncomplicated Plasmodium falciparum malaria and healthy controls.
August 2006, The American journal of tropical medicine and hygiene,
E Nikoskelainen, and J Nikoskelainen, and A A Salmi, and P E Halonen
Serum uric acid levels in optic neuritis.
June 2004, Multiple sclerosis (Houndmills, Basingstoke, England),
E Nikoskelainen, and J Nikoskelainen, and A A Salmi, and P E Halonen
Relationship between serum bilirubin levels and optic neuritis.
January 2013, Chinese medical journal,
E Nikoskelainen, and J Nikoskelainen, and A A Salmi, and P E Halonen
Redox-reactive antiphospholipid antibody differences between serum from Alzheimer's patients and age-matched controls.
January 2009, Autoimmunity,
E Nikoskelainen, and J Nikoskelainen, and A A Salmi, and P E Halonen
Virus antibodies in the serum of multiple sclerosis patients and matched controls.
April 1970, Neurology,
E Nikoskelainen, and J Nikoskelainen, and A A Salmi, and P E Halonen
Primary antiphospholipid antibody syndrome with optic neuritis.
September 2009, The Journal of the Association of Physicians of India,
E Nikoskelainen, and J Nikoskelainen, and A A Salmi, and P E Halonen
MOG antibody-associated optic neuritis.
May 2024, Eye (London, England),
E Nikoskelainen, and J Nikoskelainen, and A A Salmi, and P E Halonen
Antibody Testing in Atypical Optic Neuritis.
August 2020, Seminars in ophthalmology,
E Nikoskelainen, and J Nikoskelainen, and A A Salmi, and P E Halonen
Osteoprotegerin serum levels in multiple myeloma and MGUS patients compared with age- and sex-matched healthy controls.
September 2004, Leukemia,
Copied contents to your clipboard!