-transparent.png){kind=logo}
Collagen metabolism was studied in rat lungs during prolonged intermittent exposure to oxygen. After an initial of 2-d exposure to oxygen, the rats alternately breathed air and oxygen in 24-h periods up to 30 d. Lung histology showed perivascular edema as an early sign of oxygen toxicity. Increased capillary permeability was followed by a marked perivascular leukocytosis that was prominent between the 5th and 11th d of the treatment. During the further course of the experiment, the inflammatory response gradually diminished, and finally a network of collagen fibres filled the perivascular areas. The inflammatory process elevated the amounts of DNA and RNA in lung tissue, and the ratio of RNA to DNA was maximal on the 5th day. Studies on metabolism of lung collagen with intraperitoneally injected 3H-proline as label showed that, after the initial inflammatory reaction, both synthesis and degration of collagen were increased in oxygen-treated lungs. The increase in synthesis exceeded the rise in degradation and, therefore, collagen was accumulated. The activation of lung collagen synthesis coincided in time with a rise in the activity of lung protocollagen proline hydroxylase.
M Välimäki, and
K Juva, and
J Rantanen, and
T Ekfors, and
J Niinikoski
September 1971,
American Industrial Hygiene Association journal,
M Välimäki, and
K Juva, and
J Rantanen, and
T Ekfors, and
J Niinikoski
May 1986,
Journal of applied physiology (Bethesda, Md. : 1985),
M Välimäki, and
K Juva, and
J Rantanen, and
T Ekfors, and
J Niinikoski
January 1977,
Journal of applied physiology: respiratory, environmental and exercise physiology,
M Välimäki, and
K Juva, and
J Rantanen, and
T Ekfors, and
J Niinikoski
June 1983,
Biochemical and biophysical research communications,
M Välimäki, and
K Juva, and
J Rantanen, and
T Ekfors, and
J Niinikoski
November 1979,
Toxicology and applied pharmacology,
M Välimäki, and
K Juva, and
J Rantanen, and
T Ekfors, and
J Niinikoski
January 1977,
Anesthesia and analgesia,
M Välimäki, and
K Juva, and
J Rantanen, and
T Ekfors, and
J Niinikoski
April 1985,
Xenobiotica; the fate of foreign compounds in biological systems,
M Välimäki, and
K Juva, and
J Rantanen, and
T Ekfors, and
J Niinikoski
October 1969,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M Välimäki, and
K Juva, and
J Rantanen, and
T Ekfors, and
J Niinikoski
September 1985,
The American review of respiratory disease,
M Välimäki, and
K Juva, and
J Rantanen, and
T Ekfors, and
J Niinikoski
February 1975,
Chest,
