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A calcitonin receptor complementary DNA (cDNA) was cloned by expression of a cDNA library from a porcine kidney epithelial cell line in COS cells. The 482-amino acid receptor has high affinity for salmon calcitonin (dissociation constant Kd approximately 6 nM) and is functionally coupled to increases in intracellular cyclic adenosine monophosphate (cAMP). The receptor shows no sequence similarity to other reported G protein-coupled receptors but is homologous to the parathyroid hormone-parathyroid hormone-related peptide (PTH-PTHrP) receptor, indicating that the receptors for these hormones, which regulate calcium homeostasis, represent a new family of G protein-coupled receptors.
H Y Lin, and
T L Harris, and
M S Flannery, and
A Aruffo, and
E H Kaji, and
A Gorn, and
L F Kolakowski, and
H F Lodish, and
S R Goldring
August 1998,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
H Y Lin, and
T L Harris, and
M S Flannery, and
A Aruffo, and
E H Kaji, and
A Gorn, and
L F Kolakowski, and
H F Lodish, and
S R Goldring
August 1995,
The Biochemical journal,
H Y Lin, and
T L Harris, and
M S Flannery, and
A Aruffo, and
E H Kaji, and
A Gorn, and
L F Kolakowski, and
H F Lodish, and
S R Goldring
August 1999,
Brain research. Molecular brain research,
H Y Lin, and
T L Harris, and
M S Flannery, and
A Aruffo, and
E H Kaji, and
A Gorn, and
L F Kolakowski, and
H F Lodish, and
S R Goldring
February 1997,
Sheng li xue bao : [Acta physiologica Sinica],
H Y Lin, and
T L Harris, and
M S Flannery, and
A Aruffo, and
E H Kaji, and
A Gorn, and
L F Kolakowski, and
H F Lodish, and
S R Goldring
May 1979,
Biochemistry,
H Y Lin, and
T L Harris, and
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A Aruffo, and
E H Kaji, and
A Gorn, and
L F Kolakowski, and
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S R Goldring
January 1987,
Molecular neurobiology,
H Y Lin, and
T L Harris, and
M S Flannery, and
A Aruffo, and
E H Kaji, and
A Gorn, and
L F Kolakowski, and
H F Lodish, and
S R Goldring
November 2012,
Applied microbiology and biotechnology,
H Y Lin, and
T L Harris, and
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A Aruffo, and
E H Kaji, and
A Gorn, and
L F Kolakowski, and
H F Lodish, and
S R Goldring
June 1994,
Regulatory peptides,
H Y Lin, and
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A Aruffo, and
E H Kaji, and
A Gorn, and
L F Kolakowski, and
H F Lodish, and
S R Goldring
August 1994,
Journal of neurochemistry,
H Y Lin, and
T L Harris, and
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A Aruffo, and
E H Kaji, and
A Gorn, and
L F Kolakowski, and
H F Lodish, and
S R Goldring
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Biochemical pharmacology,
