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Inhibition of the voltage-dependent Na channel by tetrodotoxin (5 mumol/l) decreased by about 86% the stimulation of the respiration of rat brain synaptosomes induced by veratridine (10 mumol/l). A similar effect was achieved by blocking Na(+)-K(+)-ATPase with ouabain (1 mmol/l). Pharmacological manipulations of Ca homeostasis suggested that the veratridine-induced stimulation of respiration did not depend upon Ca entry. These data suggest that the veratridine-induced stimulation of synaptosomal respiration may result primarily from an increase in intracellular Na+. They provide the basis for an indirect method, which only requires recording of synaptosomal respiration, to test drugs for their possible interaction with excessive Na influxes.
J Urenjak, and
F Tegtmeier, and
A Beile, and
S Khan, and
T Peters
December 1996,
Neuroscience letters,
J Urenjak, and
F Tegtmeier, and
A Beile, and
S Khan, and
T Peters
May 1982,
Journal of neurochemistry,
J Urenjak, and
F Tegtmeier, and
A Beile, and
S Khan, and
T Peters
January 1983,
Journal of neurochemistry,
J Urenjak, and
F Tegtmeier, and
A Beile, and
S Khan, and
T Peters
August 1974,
Nature,
J Urenjak, and
F Tegtmeier, and
A Beile, and
S Khan, and
T Peters
September 2000,
Brain research,
J Urenjak, and
F Tegtmeier, and
A Beile, and
S Khan, and
T Peters
December 1996,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
J Urenjak, and
F Tegtmeier, and
A Beile, and
S Khan, and
T Peters
May 1972,
Journal of neurochemistry,
J Urenjak, and
F Tegtmeier, and
A Beile, and
S Khan, and
T Peters
August 1977,
Journal of neurochemistry,
J Urenjak, and
F Tegtmeier, and
A Beile, and
S Khan, and
T Peters
September 1993,
Journal of neurochemistry,
J Urenjak, and
F Tegtmeier, and
A Beile, and
S Khan, and
T Peters
November 1991,
European journal of pharmacology,
