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Blood induced acute and chronic cerebral vasospasm were studied in Rhesus monkeys by serial angiography. Two vasoactive agents were evaluated. In acute spasm, phosphodiesterase inhibition by Aminophylline consistently reversed the vasospasm. This agent alone was ineffective in chronic spasm and required the addition of Isoproterenol to produce reversal of vasospasm. It is proposed that cerebral vasospasm may be associated with a decrease of intracellular c-AMP in vascular smooth muscle which can be reversed by manipulation of the enzyme pathway involved. It is further proposed that c-AMP is a basic common pathway through which adrenergic vascular reactivities are mediated.
J Kim, and
E S Flamm, and
J Lin
December 1978,
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
J Kim, and
E S Flamm, and
J Lin
October 1976,
Surgical neurology,
J Kim, and
E S Flamm, and
J Lin
December 1975,
Surgical neurology,
J Kim, and
E S Flamm, and
J Lin
January 1972,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
J Kim, and
E S Flamm, and
J Lin
January 1975,
Klinicheskaia meditsina,
J Kim, and
E S Flamm, and
J Lin
December 1972,
The Journal of laboratory and clinical medicine,
J Kim, and
E S Flamm, and
J Lin
January 1970,
Pharmacology,
J Kim, and
E S Flamm, and
J Lin
January 1972,
G.E.N,
J Kim, and
E S Flamm, and
J Lin
December 1979,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
J Kim, and
E S Flamm, and
J Lin
February 1971,
Deutsche medizinische Wochenschrift (1946),
