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The leukocyte Na/H antiporter has been studied in patients with end-stage renal failure on maintenance haemodialysis. Thirteen non-diabetic haemodialysis patients (CRF group) and eight haemodialysis patients with diabetic nephropathy (CRF-DM group) were investigated. Measurements were made using the pH-sensitive fluorescent dye bis (carboxyethyl) carboxyfluorescein (BCECF). The initial intracellular pH (pHi), intracellular buffering capacity, and Na/H antiporter Vmax (at pHi = 6.0) have been recorded in bicarbonate-free solutions. The mean initial intracellular pH in the CRF group was 7.34 (SD 0.05, P less than 0.004) and this was significantly less than the CRF-DM group (7.42, SD 0.07) and normal controls (7.43, SD 0.09, n = 25). The mean intracellular buffering capacity was normal in the CRF and CRF-DM groups. The mean Na/H antiporter Vmax was also normal in the CRF and CRF-DM groups (56.5, SD 9.9; and 56.8, SD 12.8, mmol/l per min respectively compared to 55.2, SD 8.8, mmol/l per min in controls). These data are discussed with reference to the reported high values of Na/H antiporter Vmax in diabetic patients with early nephropathy. This abnormality does not appear to be present in end-stage diabetic nephropathy.
C E Poli de Figueiredo, and
L L Ng, and
M C Garrido, and
J E Davies, and
J C Ellory, and
B M Hendry
January 1992,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
C E Poli de Figueiredo, and
L L Ng, and
M C Garrido, and
J E Davies, and
J C Ellory, and
B M Hendry
January 1988,
Society of General Physiologists series,
C E Poli de Figueiredo, and
L L Ng, and
M C Garrido, and
J E Davies, and
J C Ellory, and
B M Hendry
March 1990,
The American journal of physiology,
C E Poli de Figueiredo, and
L L Ng, and
M C Garrido, and
J E Davies, and
J C Ellory, and
B M Hendry
September 1991,
The American journal of physiology,
C E Poli de Figueiredo, and
L L Ng, and
M C Garrido, and
J E Davies, and
J C Ellory, and
B M Hendry
October 1987,
The Journal of clinical investigation,
C E Poli de Figueiredo, and
L L Ng, and
M C Garrido, and
J E Davies, and
J C Ellory, and
B M Hendry
January 1990,
Progress in clinical and biological research,
C E Poli de Figueiredo, and
L L Ng, and
M C Garrido, and
J E Davies, and
J C Ellory, and
B M Hendry
December 1998,
Biology of reproduction,
C E Poli de Figueiredo, and
L L Ng, and
M C Garrido, and
J E Davies, and
J C Ellory, and
B M Hendry
January 1991,
Neuroscience,
C E Poli de Figueiredo, and
L L Ng, and
M C Garrido, and
J E Davies, and
J C Ellory, and
B M Hendry
August 1996,
Brain research,
C E Poli de Figueiredo, and
L L Ng, and
M C Garrido, and
J E Davies, and
J C Ellory, and
B M Hendry
September 1992,
Nihon rinsho. Japanese journal of clinical medicine,
