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The present study has examined the time course of autonomic tone changes in two-kidney, one-clip (2K1C) and one-kidney, one-clip (1K1C) renal hypertension. In conscious rats, cardiac sympathetic and vagal tone were determined using propranolol and atropine, respectively. The development of renovascular hypertension was accompanied by a significant tachycardia, increase in cardiac sympathetic tone and decrease in cardiac vagal tone. In the isolated perfused heart we observed a reduced chronotropic response to isoproterenol. These alterations were transitory in 2K1C and greater and more persistent in 1K1C renal hypertension. These results show the relative role played by the cardiac sympathetic and vagal systems in the maintenance of tachycardia in renovascular hypertension.
A M Cabral, and
E C Vasquez
January 1989,
The Japanese journal of physiology,
A M Cabral, and
E C Vasquez
July 2009,
Experimental physiology,
A M Cabral, and
E C Vasquez
June 1997,
Hypertension research : official journal of the Japanese Society of Hypertension,
A M Cabral, and
E C Vasquez
January 1991,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
A M Cabral, and
E C Vasquez
April 2011,
Pflugers Archiv : European journal of physiology,
A M Cabral, and
E C Vasquez
March 1990,
The American journal of physiology,
A M Cabral, and
E C Vasquez
January 2012,
PloS one,
A M Cabral, and
E C Vasquez
December 2011,
Experimental physiology,
A M Cabral, and
E C Vasquez
May 2014,
Psychophysiology,
A M Cabral, and
E C Vasquez
February 2011,
Experimental physiology,
