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[Experimental chemotherapy against human esophageal carcinoma xenografts with TS-1, cisplatin and docetaxel]. 2006
Takaya Yamada, and
Asako Masuda, and
Miki Tongu, and
Osamu Hiraku, and
Tadahiro Etou, and
Ken Sasaki, and
Koichiro Atsuda, and
Seijiro Morinaga, and
Tatsuo Suzuki, and
Yukio Suzuki, and
Masayoshi Osaku, and
Takeshi Miyagawa, and
Fumiki Asanuma, and
Yoshinori Yamada
Biomedical Laboratory, Kitasato Institute Hospital.
Three strains of human esophageal carcinoma xenografts established in our institution were tested against combination chemotherapy in vivo and in vitro. TS-1 plus cisplatin (CDDP) was shown to be an effective combination against two carcinoma strains of moderately-differentiated type. Determination of the thymidylate synthase (TS) demonstrated a higher inhibition of the enzyme by adding CDDP to 5-FU, suggesting biochemical modulation. The remaining strain of poorly-differentiated type was resistant to the combination and an attempt was made to add docetaxel (DTX) to show that the three-drug combination was effective against the strain. Combination chemotherapy including TS-1 and CDDP thus appears to be useful treatment choice for esophageal carcinoma.
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