BIOMAT Database Logo BIOMAT Database Logo

Effect of beta-endorphin on human chorionic gonadotrophin secretion by placental explants. 1991

E R Barnea, and R Ashkenazy, and Y Tal, and S Kol, and Y Sarne
University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Camden.

In the present study the effect of physiological concentrations of beta-endorphin was examined upon human chorionic gonadotrophin (HCG) secretion by first trimester placental explants. Results show that at 7-9 weeks of gestation, beta-endorphin inhibited HCG secretion; a maximal suppression of 60% was noted at 5 x 10(-10) M concentrations, while fivefold lower or higher doses were less effective. This inhibitory effect was completely reversed by naloxone, an opiate receptor antagonist, indicating involvement of an opiate receptor in the action of beta-endorphin. The opioid peptide specificity was demonstrated by the failure of N-acetyl-beta-endorphin, a non-opiate analogue used at the same concentration range, to affect HCG secretion. Following the HCG peak, at 11 weeks however, the effect of beta-endorphin was stimulatory on HCG secretion, which suggests a gestational age-dependent effect of the opioid peptide. In conclusion, these data indicate that beta-endorphin, a mu and delta opioid receptor ligand, has a modulatory effect on HCG secretion in vitro in the young placenta.

UI MeSH Term Description Entries
D009270 Naloxone A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors. MRZ 2593-Br,MRZ-2593,Nalone,Naloxon Curamed,Naloxon-Ratiopharm,Naloxone Abello,Naloxone Hydrobromide,Naloxone Hydrochloride,Naloxone Hydrochloride Dihydride,Naloxone Hydrochloride, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer,Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer,Narcan,Narcanti,Abello, Naloxone,Curamed, Naloxon,Dihydride, Naloxone Hydrochloride,Hydrobromide, Naloxone,Hydrochloride Dihydride, Naloxone,Hydrochloride, Naloxone,MRZ 2593,MRZ 2593 Br,MRZ 2593Br,MRZ2593,Naloxon Ratiopharm
D010920 Placenta A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES). Placentoma, Normal,Placentome,Placentas,Placentomes
D011957 Receptors, Opioid Cell membrane proteins that bind opioids and trigger intracellular changes which influence the behavior of cells. The endogenous ligands for opioid receptors in mammals include three families of peptides, the enkephalins, endorphins, and dynorphins. The receptor classes include mu, delta, and kappa receptors. Sigma receptors bind several psychoactive substances, including certain opioids, but their endogenous ligands are not known. Endorphin Receptors,Enkephalin Receptors,Narcotic Receptors,Opioid Receptors,Receptors, Endorphin,Receptors, Enkephalin,Receptors, Narcotic,Receptors, Opiate,Endorphin Receptor,Enkephalin Receptor,Normorphine Receptors,Opiate Receptor,Opiate Receptors,Opioid Receptor,Receptors, Normorphine,Receptors, beta-Endorphin,beta-Endorphin Receptor,Receptor, Endorphin,Receptor, Enkephalin,Receptor, Opiate,Receptor, Opioid,Receptor, beta-Endorphin,Receptors, beta Endorphin,beta Endorphin Receptor,beta-Endorphin Receptors
D005865 Gestational Age The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated from the onset of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization. It is also estimated to begin from fertilization, estrus, coitus, or artificial insemination. Embryologic Age,Fetal Maturity, Chronologic,Chronologic Fetal Maturity,Fetal Age,Maturity, Chronologic Fetal,Age, Embryologic,Age, Fetal,Age, Gestational,Ages, Embryologic,Ages, Fetal,Ages, Gestational,Embryologic Ages,Fetal Ages,Gestational Ages
D006063 Chorionic Gonadotropin A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN). Chorionic Gonadotropin, Human,HCG (Human Chorionic Gonadotropin),Biogonadil,Choriogonadotropin,Choriogonin,Chorulon,Gonabion,Human Chorionic Gonadotropin,Pregnyl,Gonadotropin, Chorionic,Gonadotropin, Human Chorionic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001615 beta-Endorphin A 31-amino acid peptide that is the C-terminal fragment of BETA-LIPOTROPIN. It acts on OPIOID RECEPTORS and is an analgesic. Its first four amino acids at the N-terminal are identical to the tetrapeptide sequence of METHIONINE ENKEPHALIN and LEUCINE ENKEPHALIN. Endorphin, beta,beta-Endorphin (1-31),beta Endorphin
D066298 In Vitro Techniques Methods to study reactions or processes taking place in an artificial environment outside the living organism. In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In

Related Publications

E R Barnea, and R Ashkenazy, and Y Tal, and S Kol, and Y Sarne
Effect of insulin on human chorionic gonadotrophin secretion by placental explants.
June 1993, Human reproduction (Oxford, England),
E R Barnea, and R Ashkenazy, and Y Tal, and S Kol, and Y Sarne
Effect of bromodichloromethane on chorionic gonadotrophin secretion by human placental trophoblast cultures.
November 2003, Toxicological sciences : an official journal of the Society of Toxicology,
E R Barnea, and R Ashkenazy, and Y Tal, and S Kol, and Y Sarne
Stimulatory effects of extracellular calcium on chorionic gonadotrophin and placental lactogen release by human placental explants.
January 1990, Placenta,
E R Barnea, and R Ashkenazy, and Y Tal, and S Kol, and Y Sarne
Colloidal effect of albumin on the placental lactogen and chorionic gonadotrophin releases from human term placental explants.
March 2004, Biochemical and biophysical research communications,
E R Barnea, and R Ashkenazy, and Y Tal, and S Kol, and Y Sarne
Modification of pulsatile human chorionic gonadotrophin secretion in first trimester placental explants induced by polycyclic aromatic hydrocarbons.
March 1992, Human reproduction (Oxford, England),
E R Barnea, and R Ashkenazy, and Y Tal, and S Kol, and Y Sarne
Patterns of secretion of human chorionic gonadotrophin by superfused placental explants and the embryo--placental relationship following maternal use of medications.
March 1992, Human reproduction (Oxford, England),
E R Barnea, and R Ashkenazy, and Y Tal, and S Kol, and Y Sarne
Factors controlling spontaneous human chorionic gonadotrophin in superfused first trimester placental explants.
August 1992, Human reproduction (Oxford, England),
E R Barnea, and R Ashkenazy, and Y Tal, and S Kol, and Y Sarne
Comparative stimulatory effect of gonadotrophin releasing hormone (GnRH) and GnRH agonist upon pulsatile human chorionic gonadotrophin secretion in superfused placental explants: reversible inhibition by a GnRH antagonist.
September 1991, Human reproduction (Oxford, England),
E R Barnea, and R Ashkenazy, and Y Tal, and S Kol, and Y Sarne
Chorionic gonadotrophin secretion by human blastocysts.
June 1993, Human reproduction (Oxford, England),
E R Barnea, and R Ashkenazy, and Y Tal, and S Kol, and Y Sarne
Physiological concentrations of albumin stimulate chorionic gonadotrophin and placental lactogen release from human term placental explants.
March 2001, Human reproduction (Oxford, England),
Copied contents to your clipboard!