BIOMAT Database Logo BIOMAT Database Logo

Significance of intracellular free calcium and magnesium and calcium-regulating hormones with sodium chloride loading in patients with essential hypertension. 1991

T Shingu, and H Matsuura, and M Kusaka, and I Inoue, and A Yuasa, and T Shingu, and T Ishida, and G Kajiyama
First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.

This study was designed: (1) to test the hypothesis that the pressor response to sodium chloride loading in patients with essential hypertension is associated with disorder of divalent cations (calcium and magnesium); and (2) to clarify the relationship between intracellular free calcium concentration and serum levels of calcium-regulating factors and intracellular magnesium concentration. With sodium chloride loading, mean blood pressure, urinary calcium and magnesium excretions and platelet calcium concentration were increased, and serum total and ionized calcium, magnesium concentrations and erythrocyte magnesium concentration were decreased. Change in mean blood pressure was correlated with changes in parathyroid hormone (r = 0.49, P less than 0.05), serum total and ionized calcium (r = -0.50, P less than 0.05) and erythrocyte magnesium (r = -0.56, P less than 0.05) and platelet calcium concentrations (r = 0.46, P less than 0.05). In addition, change in platelet calcium concentration was related to changes in parathyroid hormone (r = 0.44, P = 0.05), serum total and ionized calcium (r = -0.66, P less than 0.01) and erythrocyte magnesium concentration (r = -0.49, P less than 0.05). It is concluded that the pressor effect of excessive sodium chloride intake on blood pressure in patients with essential hypertension is associated with a disorder of divalent cations and that alteration of the intracellular free calcium concentration with sodium chloride loading may occur through handling of serum total and ionized calcium, parathyroid hormone and/or intracellular magnesium concentration.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008274 Magnesium A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
D008297 Male Males
D010281 Parathyroid Hormone A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates. Natpara,PTH (1-84),PTH(1-34),Parathormone,Parathyrin,Parathyroid Hormone (1-34),Parathyroid Hormone (1-84),Parathyroid Hormone Peptide (1-34),Hormone, Parathyroid
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D004912 Erythrocytes Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN. Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

T Shingu, and H Matsuura, and M Kusaka, and I Inoue, and A Yuasa, and T Shingu, and T Ishida, and G Kajiyama
Intracellular sodium and calcium in essential hypertension.
August 1982, Klinische Wochenschrift,
T Shingu, and H Matsuura, and M Kusaka, and I Inoue, and A Yuasa, and T Shingu, and T Ishida, and G Kajiyama
Intracellular ions in salt-sensitive essential hypertension: possible role of calcium-regulating hormones.
January 1991, Contributions to nephrology,
T Shingu, and H Matsuura, and M Kusaka, and I Inoue, and A Yuasa, and T Shingu, and T Ishida, and G Kajiyama
[Etiological significance of calcium regulating hormones in hypertension].
April 1992, Nihon rinsho. Japanese journal of clinical medicine,
T Shingu, and H Matsuura, and M Kusaka, and I Inoue, and A Yuasa, and T Shingu, and T Ishida, and G Kajiyama
Calcium-regulating hormones in essential hypertension. Relation to plasma renin activity and sodium metabolism.
November 1986, Annals of internal medicine,
T Shingu, and H Matsuura, and M Kusaka, and I Inoue, and A Yuasa, and T Shingu, and T Ishida, and G Kajiyama
Calcium regulating hormones in essential hypertension. Importance of gender.
August 1990, American journal of hypertension,
T Shingu, and H Matsuura, and M Kusaka, and I Inoue, and A Yuasa, and T Shingu, and T Ishida, and G Kajiyama
Protein phosphorylation and intracellular free calcium in platelets of patients with essential hypertension.
March 1992, American journal of hypertension,
T Shingu, and H Matsuura, and M Kusaka, and I Inoue, and A Yuasa, and T Shingu, and T Ishida, and G Kajiyama
[Intracellular free calcium and plasma calcium in patients with essential hypertension. Is there a correlation between extracellular and intracellular disorders of calcium regulation in essential hypertension?].
May 1988, Klinische Wochenschrift,
T Shingu, and H Matsuura, and M Kusaka, and I Inoue, and A Yuasa, and T Shingu, and T Ishida, and G Kajiyama
[Etiological significance of calcium and magnesium activity in essential hypertension].
April 1992, Nihon rinsho. Japanese journal of clinical medicine,
T Shingu, and H Matsuura, and M Kusaka, and I Inoue, and A Yuasa, and T Shingu, and T Ishida, and G Kajiyama
PLASMA SODIUM, POTASSIUM, CALCIUM, AND MAGNESIUM CONCENTRATIONS IN ESSENTIAL HYPERTENSION.
October 1964, The American journal of the medical sciences,
T Shingu, and H Matsuura, and M Kusaka, and I Inoue, and A Yuasa, and T Shingu, and T Ishida, and G Kajiyama
Metabolic observations in essential hypertension: sodium, chloride, potassium, water and hormones.
June 1963, Postgraduate medicine,
Copied contents to your clipboard!