Computer-aided continuous drug infusion: setup and test of a mobile closed-loop system for the continuous automated infusion of insulin. 2006

Ralf Dudde, and Thomas Vering, and Gundula Piechotta, and Rainer Hintsche
Fraunhofer Institute of Silicon Technology, D-25524 Itzehoe, Germany. ralf.dudde@isit.fraunhofer.de

For a diabetes mellitus patient, tight control of glucose level is essential. Results are reported of an investigation of the suitability of existing wearable continuous insulin infusors controlled and adjusted by a control algorithm using continuous glucose measurements as input to perform the functionality of an artificial pancreas. Special attention was given to the development of a continuous glucose monitor and to evaluate which quality of input data is necessary for the control algorithm. In clinical trials, it was found that for patients in a controlled environment an autonomously regulating control algorithm leads to an improved adjustment of patient glucose values and less overall insulin infusion as compared with the best fixed preprogrammed insulin infusion profiles of standard pump therapy. For the limited number of cases studied here, functionality of the control algorithm could tolerate some delay between the actual glucose values in the patient interstitial fluid and the algorithm input of up to 30 min. A quasicontinuous glucose measurement delivering actual glucose values every 5-10 min seems to be suited to control an artificial pancreas.

UI MeSH Term Description Entries
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D007332 Insulin Infusion Systems Portable or implantable devices for infusion of insulin. Includes open-loop systems which may be patient-operated or controlled by a pre-set program and are designed for constant delivery of small quantities of insulin, increased during food ingestion, and closed-loop systems which deliver quantities of insulin automatically based on an electronic glucose sensor. Pancreas, Artificial Endocrine,Programmable Implantable Insulin Pump,beta Cell, Artificial,Implantable Programmable Insulin Pump,Insulin Pump, Programmable Implantable,Pump, Programmable Implantable Insulin,Artificial Endocrine Pancreas,Artificial beta Cell,Artificial beta Cells,Cell, Artificial beta,Cells, Artificial beta,Endocrine Pancreas, Artificial,Infusion System, Insulin,Infusion Systems, Insulin,Insulin Infusion System,System, Insulin Infusion,Systems, Insulin Infusion,beta Cells, Artificial
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D003920 Diabetes Mellitus A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
D004360 Drug Therapy, Computer-Assisted Adjunctive computer programs in providing drug treatment to patients. Computer-Assisted Drug Therapy,Protocol Drug Therapy, Computer-Assisted,Therapy, Computer-Assisted Drug,Computer Assisted Drug Therapy,Computer-Assisted Drug Therapies,Drug Therapies, Computer-Assisted,Drug Therapy, Computer Assisted,Protocol Drug Therapy, Computer Assisted,Therapies, Computer-Assisted Drug,Therapy, Computer Assisted Drug
D004867 Equipment Design Methods and patterns of fabricating machines and related hardware. Design, Equipment,Device Design,Medical Device Design,Design, Medical Device,Designs, Medical Device,Device Design, Medical,Device Designs, Medical,Medical Device Designs,Design, Device,Designs, Device,Designs, Equipment,Device Designs,Equipment Designs
D005246 Feedback A mechanism of communication within a system in that the input signal generates an output response which returns to influence the continued activity or productivity of that system. Feedbacks
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000465 Algorithms A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task. Algorithm
D000553 Ambulatory Care Health care services provided to patients on an ambulatory basis, rather than by admission to a hospital or other health care facility. The services may be a part of a hospital, augmenting its inpatient services, or may be provided at a free-standing facility. Outpatient Care,Outpatient Health Services,Clinic Visits,Health Services, Outpatient,Outpatient Services,Services, Outpatient Health,Urgent Care,Care, Ambulatory,Care, Outpatient,Care, Urgent,Cares, Urgent,Clinic Visit,Health Service, Outpatient,Outpatient Health Service,Outpatient Service,Service, Outpatient,Service, Outpatient Health,Services, Outpatient,Urgent Cares,Visit, Clinic,Visits, Clinic

Related Publications

Ralf Dudde, and Thomas Vering, and Gundula Piechotta, and Rainer Hintsche
April 2024, Med (New York, N.Y.),
Ralf Dudde, and Thomas Vering, and Gundula Piechotta, and Rainer Hintsche
October 2017, BMC anesthesiology,
Ralf Dudde, and Thomas Vering, and Gundula Piechotta, and Rainer Hintsche
November 1993, Mayo Clinic proceedings,
Ralf Dudde, and Thomas Vering, and Gundula Piechotta, and Rainer Hintsche
January 1984, The Medical journal of Australia,
Ralf Dudde, and Thomas Vering, and Gundula Piechotta, and Rainer Hintsche
January 1979, Hormone and metabolic research. Supplement series,
Ralf Dudde, and Thomas Vering, and Gundula Piechotta, and Rainer Hintsche
November 2022, BMC medical informatics and decision making,
Ralf Dudde, and Thomas Vering, and Gundula Piechotta, and Rainer Hintsche
January 1985, Life support systems : the journal of the European Society for Artificial Organs,
Ralf Dudde, and Thomas Vering, and Gundula Piechotta, and Rainer Hintsche
August 1987, IEEE transactions on bio-medical engineering,
Ralf Dudde, and Thomas Vering, and Gundula Piechotta, and Rainer Hintsche
January 1993, Journal of rehabilitation research and development,
Ralf Dudde, and Thomas Vering, and Gundula Piechotta, and Rainer Hintsche
October 2016, Molecular informatics,
Copied contents to your clipboard!