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BACKGROUND The aim of our study was to measure the serum paracetamol concentrations achieved following a single rectal loading dose of 40 mg x kg(-1) in children with chronic liver disease. METHODS We recruited 17 children (3-15 years, 10.6-75 kg) undergoing minor surgical procedures under general anesthesia. Paracetamol was administered at the end of surgery and blood samples were taken for analysis at 2, 3, 4, 6 and 8 h postdose. RESULTS The mean Cmax of 11.4 mg x l(-1) [coefficient of variation (CV) 66%] was achieved at a Tmax of 2.7 h (CV 42%). The relative bioavailability (F) of the suppository formulation was not estimated, but clearance (Cl/F) estimates 0.73 l x kg(-1) x h(-1) (CV 87%) and time-concentration profiles for these children were similar to the normal pediatric population. CONCLUSIONS There are currently no biologic markers available for monitoring possible hepatotoxicity in this cohort of patients with liver disease, but our data suggest that a single-dose suppository is a satisfactory analgesic alternative.
C R H Cormack, and
S Sudan, and
R Addison, and
J Keating, and
R A Sherwood, and
E M C Ashley, and
Tanya Howell
January 2003,
Anaesthesia,
C R H Cormack, and
S Sudan, and
R Addison, and
J Keating, and
R A Sherwood, and
E M C Ashley, and
Tanya Howell
June 2003,
Anaesthesia,
C R H Cormack, and
S Sudan, and
R Addison, and
J Keating, and
R A Sherwood, and
E M C Ashley, and
Tanya Howell
February 2000,
Anesthesia and analgesia,
C R H Cormack, and
S Sudan, and
R Addison, and
J Keating, and
R A Sherwood, and
E M C Ashley, and
Tanya Howell
September 2010,
Anaesthesia and intensive care,
C R H Cormack, and
S Sudan, and
R Addison, and
J Keating, and
R A Sherwood, and
E M C Ashley, and
Tanya Howell
December 1987,
European heart journal,
C R H Cormack, and
S Sudan, and
R Addison, and
J Keating, and
R A Sherwood, and
E M C Ashley, and
Tanya Howell
January 2002,
Paediatric anaesthesia,
C R H Cormack, and
S Sudan, and
R Addison, and
J Keating, and
R A Sherwood, and
E M C Ashley, and
Tanya Howell
May 2007,
British journal of anaesthesia,
C R H Cormack, and
S Sudan, and
R Addison, and
J Keating, and
R A Sherwood, and
E M C Ashley, and
Tanya Howell
May 2012,
British journal of anaesthesia,
C R H Cormack, and
S Sudan, and
R Addison, and
J Keating, and
R A Sherwood, and
E M C Ashley, and
Tanya Howell
September 2009,
Antimicrobial agents and chemotherapy,
C R H Cormack, and
S Sudan, and
R Addison, and
J Keating, and
R A Sherwood, and
E M C Ashley, and
Tanya Howell
April 2007,
International journal of clinical pharmacology and therapeutics,
