-transparent.png){kind=logo}
Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo. 2006
Steffen Massberg, and
Ildiko Konrad, and
Katrin Schürzinger, and
Michael Lorenz, and
Simon Schneider, and
Dietlind Zohlnhoefer, and
Katharina Hoppe, and
Matthias Schiemann, and
Elisabeth Kennerknecht, and
Susanne Sauer, and
Christian Schulz, and
Sandra Kerstan, and
Martina Rudelius, and
Stefan Seidl, and
Falko Sorge, and
Harald Langer, and
Mario Peluso, and
Pankaj Goyal, and
Dietmar Vestweber, and
Nikla R Emambokus, and
Dirk H Busch, and
Jon Frampton, and
Meinrad Gawaz
Deutsches Herzzentrum and Medizinische Klinik, Technical University of Munich, D-80636 Munich, Germany. massberg@cbr.med.harvard.edu
The accumulation of smooth muscle and endothelial cells is essential for remodeling and repair of injured blood vessel walls. Bone marrow-derived progenitor cells have been implicated in vascular repair and remodeling; however, the mechanisms underlying their recruitment to the site of injury remain elusive. Here, using real-time in vivo fluorescence microscopy, we show that platelets provide the critical signal that recruits CD34+ bone marrow cells and c-Kit+ Sca-1+ Lin- bone marrow-derived progenitor cells to sites of vascular injury. Correspondingly, specific inhibition of platelet adhesion virtually abrogated the accumulation of both CD34+ and c-Kit+ Sca-1+ Lin- bone marrow-derived progenitor cells at sites of endothelial disruption. Binding of bone marrow cells to platelets involves both P-selectin and GPIIb integrin on platelets. Unexpectedly, we found that activated platelets secrete the chemokine SDF-1alpha, thereby supporting further primary adhesion and migration of progenitor cells. These findings establish the platelet as a major player in the initiation of vascular remodeling, a process of fundamental importance for vascular repair and pathological remodeling after vascular injury.
Related Publications
Steffen Massberg, and
Ildiko Konrad, and
Katrin Schürzinger, and
Michael Lorenz, and
Simon Schneider, and
Dietlind Zohlnhoefer, and
Katharina Hoppe, and
Matthias Schiemann, and
Elisabeth Kennerknecht, and
Susanne Sauer, and
Christian Schulz, and
Sandra Kerstan, and
Martina Rudelius, and
Stefan Seidl, and
Falko Sorge, and
Harald Langer, and
Mario Peluso, and
Pankaj Goyal, and
Dietmar Vestweber, and
Nikla R Emambokus, and
Dirk H Busch, and
Jon Frampton, and
Meinrad Gawaz
March 2005,
The Journal of allergy and clinical immunology,
Steffen Massberg, and
Ildiko Konrad, and
Katrin Schürzinger, and
Michael Lorenz, and
Simon Schneider, and
Dietlind Zohlnhoefer, and
Katharina Hoppe, and
Matthias Schiemann, and
Elisabeth Kennerknecht, and
Susanne Sauer, and
Christian Schulz, and
Sandra Kerstan, and
Martina Rudelius, and
Stefan Seidl, and
Falko Sorge, and
Harald Langer, and
Mario Peluso, and
Pankaj Goyal, and
Dietmar Vestweber, and
Nikla R Emambokus, and
Dirk H Busch, and
Jon Frampton, and
Meinrad Gawaz
March 2001,
Experimental hematology,
Steffen Massberg, and
Ildiko Konrad, and
Katrin Schürzinger, and
Michael Lorenz, and
Simon Schneider, and
Dietlind Zohlnhoefer, and
Katharina Hoppe, and
Matthias Schiemann, and
Elisabeth Kennerknecht, and
Susanne Sauer, and
Christian Schulz, and
Sandra Kerstan, and
Martina Rudelius, and
Stefan Seidl, and
Falko Sorge, and
Harald Langer, and
Mario Peluso, and
Pankaj Goyal, and
Dietmar Vestweber, and
Nikla R Emambokus, and
Dirk H Busch, and
Jon Frampton, and
Meinrad Gawaz
December 1990,
The Keio journal of medicine,
Steffen Massberg, and
Ildiko Konrad, and
Katrin Schürzinger, and
Michael Lorenz, and
Simon Schneider, and
Dietlind Zohlnhoefer, and
Katharina Hoppe, and
Matthias Schiemann, and
Elisabeth Kennerknecht, and
Susanne Sauer, and
Christian Schulz, and
Sandra Kerstan, and
Martina Rudelius, and
Stefan Seidl, and
Falko Sorge, and
Harald Langer, and
Mario Peluso, and
Pankaj Goyal, and
Dietmar Vestweber, and
Nikla R Emambokus, and
Dirk H Busch, and
Jon Frampton, and
Meinrad Gawaz
March 2007,
Seminars in thrombosis and hemostasis,
Steffen Massberg, and
Ildiko Konrad, and
Katrin Schürzinger, and
Michael Lorenz, and
Simon Schneider, and
Dietlind Zohlnhoefer, and
Katharina Hoppe, and
Matthias Schiemann, and
Elisabeth Kennerknecht, and
Susanne Sauer, and
Christian Schulz, and
Sandra Kerstan, and
Martina Rudelius, and
Stefan Seidl, and
Falko Sorge, and
Harald Langer, and
Mario Peluso, and
Pankaj Goyal, and
Dietmar Vestweber, and
Nikla R Emambokus, and
Dirk H Busch, and
Jon Frampton, and
Meinrad Gawaz
August 2010,
Diabetes,
Steffen Massberg, and
Ildiko Konrad, and
Katrin Schürzinger, and
Michael Lorenz, and
Simon Schneider, and
Dietlind Zohlnhoefer, and
Katharina Hoppe, and
Matthias Schiemann, and
Elisabeth Kennerknecht, and
Susanne Sauer, and
Christian Schulz, and
Sandra Kerstan, and
Martina Rudelius, and
Stefan Seidl, and
Falko Sorge, and
Harald Langer, and
Mario Peluso, and
Pankaj Goyal, and
Dietmar Vestweber, and
Nikla R Emambokus, and
Dirk H Busch, and
Jon Frampton, and
Meinrad Gawaz
May 2001,
Blood,
Steffen Massberg, and
Ildiko Konrad, and
Katrin Schürzinger, and
Michael Lorenz, and
Simon Schneider, and
Dietlind Zohlnhoefer, and
Katharina Hoppe, and
Matthias Schiemann, and
Elisabeth Kennerknecht, and
Susanne Sauer, and
Christian Schulz, and
Sandra Kerstan, and
Martina Rudelius, and
Stefan Seidl, and
Falko Sorge, and
Harald Langer, and
Mario Peluso, and
Pankaj Goyal, and
Dietmar Vestweber, and
Nikla R Emambokus, and
Dirk H Busch, and
Jon Frampton, and
Meinrad Gawaz
December 2009,
Tissue engineering. Part C, Methods,
Steffen Massberg, and
Ildiko Konrad, and
Katrin Schürzinger, and
Michael Lorenz, and
Simon Schneider, and
Dietlind Zohlnhoefer, and
Katharina Hoppe, and
Matthias Schiemann, and
Elisabeth Kennerknecht, and
Susanne Sauer, and
Christian Schulz, and
Sandra Kerstan, and
Martina Rudelius, and
Stefan Seidl, and
Falko Sorge, and
Harald Langer, and
Mario Peluso, and
Pankaj Goyal, and
Dietmar Vestweber, and
Nikla R Emambokus, and
Dirk H Busch, and
Jon Frampton, and
Meinrad Gawaz
January 2008,
Stem cells (Dayton, Ohio),
Steffen Massberg, and
Ildiko Konrad, and
Katrin Schürzinger, and
Michael Lorenz, and
Simon Schneider, and
Dietlind Zohlnhoefer, and
Katharina Hoppe, and
Matthias Schiemann, and
Elisabeth Kennerknecht, and
Susanne Sauer, and
Christian Schulz, and
Sandra Kerstan, and
Martina Rudelius, and
Stefan Seidl, and
Falko Sorge, and
Harald Langer, and
Mario Peluso, and
Pankaj Goyal, and
Dietmar Vestweber, and
Nikla R Emambokus, and
Dirk H Busch, and
Jon Frampton, and
Meinrad Gawaz
May 2008,
Stem cells (Dayton, Ohio),
Steffen Massberg, and
Ildiko Konrad, and
Katrin Schürzinger, and
Michael Lorenz, and
Simon Schneider, and
Dietlind Zohlnhoefer, and
Katharina Hoppe, and
Matthias Schiemann, and
Elisabeth Kennerknecht, and
Susanne Sauer, and
Christian Schulz, and
Sandra Kerstan, and
Martina Rudelius, and
Stefan Seidl, and
Falko Sorge, and
Harald Langer, and
Mario Peluso, and
Pankaj Goyal, and
Dietmar Vestweber, and
Nikla R Emambokus, and
Dirk H Busch, and
Jon Frampton, and
Meinrad Gawaz
April 2009,
Stem cells (Dayton, Ohio),
