Biomaterial Database

Lipid rafts: membrane triage centers. 2006

Xiao-Qi Wang, and Amy S Paller

Department of Dermatology, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Avenue, Chicago, IL 60611, USA.

Both biochemical and live cell imaging studies suggest the existence of lipid rafts, specialized membrane microdomains that promote interaction among signaling molecules. Although their composition is still poorly understood, these highly dynamic domains are enriched in cholesterol, sphingolipids, and particular groups of proteins. The mechanism(s) by which trafficking into or out of lipid rafts affects signaling remains unclear.

UI	MeSH Term	Description	Entries
D008024	Ligands	A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)	Ligand
D005679	G(M3) Ganglioside	A ganglioside present in abnormally large amounts in the brain and liver due to a deficient biosynthetic enzyme, G(M3):UDP-N-acetylgalactosaminyltransferase. Deficiency of this enzyme prevents the formation of G(M2) ganglioside from G(M3) ganglioside and is the cause of an anabolic sphingolipidosis.	Hematoside,Sialyllactosylceramide,Ganglioside GM3,II3NeuAcLacCer,Sialyl Lactosylceramide,GM3, Ganglioside,Lactosylceramide, Sialyl
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D047392	beta-Cyclodextrins	Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.	beta Cyclodextrins
D051861	Kangai-1 Protein	A widely expressed transmembrane glycoprotein that functions as a METASTASIS suppressor protein. It is underexpressed in a variety of human NEOPLASMS.	Antigens, CD82,CD82 Antigen,KAI1 Protein,Antigen, CD82,CD82 Antigens,Kangai 1 Protein
D021962	Membrane Microdomains	Detergent-insoluble CELL MEMBRANE components. They are enriched in SPHINGOLIPIDS and CHOLESTEROL and clustered with glycosyl-phosphatidylinositol (GPI)-anchored proteins.	Lipid Rafts, Cell Membrane,Sphingolipid Microdomains,Sphingolipid-Cholesterol Rafts,Membrane Microdomain,Microdomain, Membrane,Microdomain, Sphingolipid,Microdomains, Membrane,Microdomains, Sphingolipid,Sphingolipid Cholesterol Rafts,Sphingolipid Microdomain,Sphingolipid-Cholesterol Raft
D066246	ErbB Receptors	A family of structurally related cell-surface receptors that signal through an intrinsic PROTEIN-TYROSINE KINASE. The receptors are activated upon binding of specific ligands which include EPIDERMAL GROWTH FACTORS, and NEUREGULINS.	EGF Receptor,Epidermal Growth Factor Receptor,Epidermal Growth Factor Receptor Family Protein,Epidermal Growth Factor Receptor Protein-Tyrosine Kinase,ErbB Receptor,HER Family Receptor,Receptor, EGF,Receptor, Epidermal Growth Factor,Receptor, TGF-alpha,Receptor, Transforming-Growth Factor alpha,Receptor, Urogastrone,Receptors, Epidermal Growth Factor-Urogastrone,TGF-alpha Receptor,Transforming Growth Factor alpha Receptor,Urogastrone Receptor,c-erbB-1 Protein,erbB-1 Proto-Oncogene Protein,EGF Receptors,Epidermal Growth Factor Receptor Family Proteins,Epidermal Growth Factor Receptor Kinase,HER Family Receptors,Proto-oncogene c-ErbB-1 Protein,Receptor Tyrosine-protein Kinase erbB-1,Receptor, ErbB-1,Receptors, Epidermal Growth Factor,Epidermal Growth Factor Receptor Protein Tyrosine Kinase,ErbB-1 Receptor,Family Receptor, HER,Family Receptors, HER,Proto oncogene c ErbB 1 Protein,Proto-Oncogene Protein, erbB-1,Receptor Tyrosine protein Kinase erbB 1,Receptor, ErbB,Receptor, ErbB 1,Receptor, HER Family,Receptor, TGF alpha,Receptor, Transforming Growth Factor alpha,Receptors, EGF,Receptors, Epidermal Growth Factor Urogastrone,Receptors, ErbB,Receptors, HER Family,c erbB 1 Protein,c-ErbB-1 Protein, Proto-oncogene,erbB 1 Proto Oncogene Protein