Biomaterial Database

[Biodegradable polymers for colon-specific drug delivery]. 2005

Witold Musiał, and Aleksander Kubis

Katedra Farmacji Stosowanej, Zakład Technologii Postaci Leku we Wrocławiu. witold@bf.uni.wroc.pl

This review focuses on the colonic drug delivery, especially using biodegradable polymers i.e. guar gum, chondroitin sulfate, pectin, starch and amylose, dextran, chitosan, inulin. Basics of colon-specific targeting, formulation aspects, microflora influence and application of cross-linking techniques and polymer mixtures for targeting drugs into the colon are presented. Adventages and disadventages of colon-specific drug delivery are also described. A number of polymers is important in the context of colon-specific drug delivery. Considerable progress has been made over last three decades in this area. Although extensive investigations have to be done in the area of microflora endogenous ecosystems and enzymatic science, immunoactivity of biopolymers, and absorption enhancers for colonic mucous. Completely synthetic polymers of good swelling properties and sensitive to bacterial enzymes are also possible in the close future.

UI	MeSH Term	Description	Entries
D008422	Materials Testing	The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.	Biocompatibility Testing,Biocompatible Materials Testing,Hemocompatibility Testing,Testing, Biocompatible Materials,Testing, Hemocompatible Materials,Hemocompatibility Testings,Hemocompatible Materials Testing,Materials Testing, Biocompatible,Materials Testing, Hemocompatible,Testing, Biocompatibility,Testing, Hemocompatibility,Testing, Materials,Testings, Biocompatibility
D011134	Polysaccharides	Long chain polymeric CARBOHYDRATES composed of MONOSACCHARIDES linked by glycosidic bonds.	Glycan,Glycans,Polysaccharide
D002626	Chemistry, Pharmaceutical	Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.	Medicinal Chemistry,Chemistry, Pharmaceutic,Pharmaceutic Chemistry,Pharmaceutical Chemistry,Chemistry, Medicinal
D003108	Colonic Diseases	Pathological processes in the COLON region of the large intestine (INTESTINE, LARGE).	Colonic Disease,Disease, Colonic,Diseases, Colonic
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001704	Biopolymers	Polymers synthesized by living organisms. They play a role in the formation of macromolecular structures and are synthesized via the covalent linkage of biological molecules, especially AMINO ACIDS; NUCLEOTIDES; and CARBOHYDRATES.	Bioplastics,Bioplastic,Biopolymer
D016503	Drug Delivery Systems	Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.	Drug Targeting,Delivery System, Drug,Delivery Systems, Drug,Drug Delivery System,Drug Targetings,System, Drug Delivery,Systems, Drug Delivery,Targeting, Drug,Targetings, Drug
D020341	Absorbable Implants	Implants constructed of materials designed to be absorbed by the body without producing an immune response. They are usually composed of plastics and are frequently used in orthopedics and orthodontics.	Bioabsorbable Implants,Biodegradable Implants,Implants, Absorbable,Absorbable Implant,Bioabsorbable Implant,Biodegradable Implant,Implant, Absorbable,Implant, Bioabsorbable,Implant, Biodegradable,Implants, Bioabsorbable,Implants, Biodegradable