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Infection of domestic cats with the feline immunodeficiency virus (FIV) represents an important veterinary health problem and a useful animal model for the development of vaccines against acquired immunodeficiency syndrome (AIDS). Two experimental FIV vaccines have been developed; one consisting of fixed infected cells (Vaccine 1), the other of inactivated whole virus (Vaccine 2). After 4-6 immunizations over 2-5 months, both vaccines induced a strong FIV-specific immune response including neutralizing antibody and T-cell proliferation. Vaccine 1 protected 6 of 9 and Vaccine 2 protected 5 of 6 recipient cats against any detectable infection with a low dose (10 animal ID50) of FIV given intraperitoneally 2 weeks after the final boost. One additional cat in each vaccine group had a transient infection at 5-7 weeks postchallenge following which virus could no longer be detected. Thus, a total of 13 of 15 vaccinated cats were protected against persistent infection. By contrast, 13 of 13 controls were persistently infected by this challenge. The infected cell vaccine failed to protect against a higher dose (5 x 10(4) ID50) of FIV. These results indicate that vaccine prophylaxis against natural FIV infection should be achievable and enhance optimism of the prospect of developing an effective AIDS vaccine for humans.
J K Yamamoto, and
T Okuda, and
C D Ackley, and
H Louie, and
E Pembroke, and
H Zochlinski, and
R J Munn, and
M B Gardner
August 2007,
Australian veterinary journal,
J K Yamamoto, and
T Okuda, and
C D Ackley, and
H Louie, and
E Pembroke, and
H Zochlinski, and
R J Munn, and
M B Gardner
January 1993,
Journal of virology,
J K Yamamoto, and
T Okuda, and
C D Ackley, and
H Louie, and
E Pembroke, and
H Zochlinski, and
R J Munn, and
M B Gardner
January 2007,
Australian veterinary journal,
J K Yamamoto, and
T Okuda, and
C D Ackley, and
H Louie, and
E Pembroke, and
H Zochlinski, and
R J Munn, and
M B Gardner
June 2007,
Australian veterinary journal,
J K Yamamoto, and
T Okuda, and
C D Ackley, and
H Louie, and
E Pembroke, and
H Zochlinski, and
R J Munn, and
M B Gardner
August 1989,
Proceedings of the National Academy of Sciences of the United States of America,
J K Yamamoto, and
T Okuda, and
C D Ackley, and
H Louie, and
E Pembroke, and
H Zochlinski, and
R J Munn, and
M B Gardner
January 1994,
The British veterinary journal,
J K Yamamoto, and
T Okuda, and
C D Ackley, and
H Louie, and
E Pembroke, and
H Zochlinski, and
R J Munn, and
M B Gardner
April 1993,
Journal of virology,
J K Yamamoto, and
T Okuda, and
C D Ackley, and
H Louie, and
E Pembroke, and
H Zochlinski, and
R J Munn, and
M B Gardner
April 2005,
Australian veterinary journal,
J K Yamamoto, and
T Okuda, and
C D Ackley, and
H Louie, and
E Pembroke, and
H Zochlinski, and
R J Munn, and
M B Gardner
January 2005,
Australian veterinary journal,
J K Yamamoto, and
T Okuda, and
C D Ackley, and
H Louie, and
E Pembroke, and
H Zochlinski, and
R J Munn, and
M B Gardner
November 1997,
Veterinary microbiology,
