Biomaterial Database

Expected and observed changes to descriptors of trabecular architecture with aging--a comparison of measurement techniques. 2006

A Badiei, and M J Bottema, and N L Fazzalari

Bone & Joint Research Laboratory, Institute of Medical & Veterinary Science, Adelaide, Australia. arash.badiei@imvs.sa.gov.au

The fragility of trabecular bone depends not only on the amount of bone but also on its architecture. In order to assess fragility of bone, describe changes due to age, and monitor effect of disease or treatment, it is necessary to model the physical properties of trabecular bone architecture. An important feature of bone architecture is the degree of anisotropy (DA). Estimates of DA may be obtained from computed tomography data by characterizing orientation in images. Widely used image descriptors for estimating orientation in this setting include mean intercept length (MIL), line fraction deviation (LFD), star length distribution (SLD) and star volume distribution (SVD). In this study, estimates of DA computed via each of these image descriptors are compared on synthetic images for various combinations of trabecular thickness, separation and number. Estimates of DA are also computed for real images representing different stages of aging. It is found that estimates of DA vary substantially depending on the choice of image descriptor. In particular, the MIL tends to underestimate DA.

UI	MeSH Term	Description	Entries
D008159	Lumbar Vertebrae	VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.	Vertebrae, Lumbar
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D011857	Radiographic Image Interpretation, Computer-Assisted	Computer systems or networks designed to provide radiographic interpretive information.	Computer Assisted Radiographic Image Interpretation,Computer-Assisted Radiographic Image Interpretation,Radiographic Image Interpretation, Computer Assisted
D001846	Bone Development	The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.	Bone Growth
D002102	Cadaver	A dead body, usually a human body.	Corpse,Cadavers,Corpses
D002113	Calcification, Physiologic	Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.	Bone Mineralization,Calcification, Physiological,Physiologic Calcification,Mineralization, Bone,Physiological Calcification
D003198	Computer Simulation	Computer-based representation of physical systems and phenomena such as chemical processes.	Computational Modeling,Computational Modelling,Computer Models,In silico Modeling,In silico Models,In silico Simulation,Models, Computer,Computerized Models,Computer Model,Computer Simulations,Computerized Model,In silico Model,Model, Computer,Model, Computerized,Model, In silico,Modeling, Computational,Modeling, In silico,Modelling, Computational,Simulation, Computer,Simulation, In silico,Simulations, Computer
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000375	Aging	The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	Senescence,Aging, Biological,Biological Aging
D001696	Biomechanical Phenomena	The properties, processes, and behavior of biological systems under the action of mechanical forces.	Biomechanics,Kinematics,Biomechanic Phenomena,Mechanobiological Phenomena,Biomechanic,Biomechanic Phenomenas,Phenomena, Biomechanic,Phenomena, Biomechanical,Phenomena, Mechanobiological,Phenomenas, Biomechanic