Exhaustion of the Frank-Starling mechanism in conscious dogs with heart failure induced by chronic coronary microembolization. 2006

Robert M Gill, and Bonita D Jones, and Angela K Corbly, and Dan G Ohad, and Gerald D Smith, and George E Sandusky, and Michael E Christe, and Jie Wang, and Weiqun Shen
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.

The role of the Frank-Starling mechanism in the regulation of cardiac systolic function in the ischemic failing heart was examined in conscious dogs. Left ventricular (LV) dimension, pressure and systolic function were assessed using surgically implanted instrumentations and non-invasive echocardiogram. Heart failure was induced by daily intra-coronary injections of microspheres for 3-4 weeks via implanted coronary catheters. Chronic coronary embolization resulted in a progressive dilation of the left ventricle (12+/-3%), increase in LV end-diastolic pressure (118+/-19%), depression of LV dP/dt(max) (-19+/-4%), fractional shortening (-36+/-7%), and cardiac work (-60+/-9%), and development of heart failure, while the LV contractile response to dobutamine was depressed. A brief inferior vena caval occlusion in dogs with heart failure decreased LV preload to match the levels attained in their control state and caused a further reduction of LV dP/dt(max), fractional shortening, stroke work and cardiac work. Moreover, in response to acute volume loading, the change in the LV end-diastolic dimension-pressure (DeltaLVEDD-DeltaLVEDP) curve in the failing heart became steeper and shifted significantly to the left, while the increases in LV stroke work and cardiac work were blunted. Thus, our results suggest that the Frank-Starling mechanism is exhausted in heart failure and unable to further respond to increasing volume while it plays an important compensatory role in adaptation to LV dysfunction in heart failure.

UI MeSH Term Description Entries
D008297 Male Males
D002303 Cardiac Output, Low A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities. Low Cardiac Output,Low Cardiac Output Syndrome,Output, Low Cardiac
D003331 Coronary Vessels The veins and arteries of the HEART. Coronary Arteries,Sinus Node Artery,Coronary Veins,Arteries, Coronary,Arteries, Sinus Node,Artery, Coronary,Artery, Sinus Node,Coronary Artery,Coronary Vein,Coronary Vessel,Sinus Node Arteries,Vein, Coronary,Veins, Coronary,Vessel, Coronary,Vessels, Coronary
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D004617 Embolism Blocking of a blood vessel by an embolus which can be a blood clot or other undissolved material in the blood stream. Embolus,Embolisms
D006352 Heart Ventricles The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation. Cardiac Ventricle,Cardiac Ventricles,Heart Ventricle,Left Ventricle,Right Ventricle,Left Ventricles,Right Ventricles,Ventricle, Cardiac,Ventricle, Heart,Ventricle, Left,Ventricle, Right,Ventricles, Cardiac,Ventricles, Heart,Ventricles, Left,Ventricles, Right
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013318 Stroke Volume The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume. Ventricular Ejection Fraction,Ventricular End-Diastolic Volume,Ventricular End-Systolic Volume,Ejection Fraction, Ventricular,Ejection Fractions, Ventricular,End-Diastolic Volume, Ventricular,End-Diastolic Volumes, Ventricular,End-Systolic Volume, Ventricular,End-Systolic Volumes, Ventricular,Fraction, Ventricular Ejection,Fractions, Ventricular Ejection,Stroke Volumes,Ventricular Ejection Fractions,Ventricular End Diastolic Volume,Ventricular End Systolic Volume,Ventricular End-Diastolic Volumes,Ventricular End-Systolic Volumes,Volume, Stroke,Volume, Ventricular End-Diastolic,Volume, Ventricular End-Systolic,Volumes, Stroke,Volumes, Ventricular End-Diastolic,Volumes, Ventricular End-Systolic
D014682 Vena Cava, Inferior The venous trunk which receives blood from the lower extremities and from the pelvic and abdominal organs. Inferior Vena Cava,Inferior Vena Cavas,Vena Cavas, Inferior

Related Publications

Robert M Gill, and Bonita D Jones, and Angela K Corbly, and Dan G Ohad, and Gerald D Smith, and George E Sandusky, and Michael E Christe, and Jie Wang, and Weiqun Shen
October 1993, The American journal of physiology,
Robert M Gill, and Bonita D Jones, and Angela K Corbly, and Dan G Ohad, and Gerald D Smith, and George E Sandusky, and Michael E Christe, and Jie Wang, and Weiqun Shen
April 1978, The American journal of physiology,
Robert M Gill, and Bonita D Jones, and Angela K Corbly, and Dan G Ohad, and Gerald D Smith, and George E Sandusky, and Michael E Christe, and Jie Wang, and Weiqun Shen
January 1990, The American journal of physiology,
Robert M Gill, and Bonita D Jones, and Angela K Corbly, and Dan G Ohad, and Gerald D Smith, and George E Sandusky, and Michael E Christe, and Jie Wang, and Weiqun Shen
April 2008, The International journal of artificial organs,
Robert M Gill, and Bonita D Jones, and Angela K Corbly, and Dan G Ohad, and Gerald D Smith, and George E Sandusky, and Michael E Christe, and Jie Wang, and Weiqun Shen
February 1998, Cardiovascular research,
Robert M Gill, and Bonita D Jones, and Angela K Corbly, and Dan G Ohad, and Gerald D Smith, and George E Sandusky, and Michael E Christe, and Jie Wang, and Weiqun Shen
September 2006, Biophysical journal,
Robert M Gill, and Bonita D Jones, and Angela K Corbly, and Dan G Ohad, and Gerald D Smith, and George E Sandusky, and Michael E Christe, and Jie Wang, and Weiqun Shen
June 2020, Circulation journal : official journal of the Japanese Circulation Society,
Robert M Gill, and Bonita D Jones, and Angela K Corbly, and Dan G Ohad, and Gerald D Smith, and George E Sandusky, and Michael E Christe, and Jie Wang, and Weiqun Shen
April 1991, Journal of the American College of Cardiology,
Robert M Gill, and Bonita D Jones, and Angela K Corbly, and Dan G Ohad, and Gerald D Smith, and George E Sandusky, and Michael E Christe, and Jie Wang, and Weiqun Shen
January 1978, Circulation research,
Robert M Gill, and Bonita D Jones, and Angela K Corbly, and Dan G Ohad, and Gerald D Smith, and George E Sandusky, and Michael E Christe, and Jie Wang, and Weiqun Shen
October 2002, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society,
Copied contents to your clipboard!