Geranylgeranylacetone, an inducer of HSP 70, attenuates REM sleep rebound after sleep deprivation. 2006

Tadashi Wada, and Hiroyoshi Sei, and Kenji Kusumoto, and Kazuyoshi Kitaoka, and Sachiko Chikahisa, and Kazuhito Rokutan, and Yusuke Morita
Department of Integrative Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.

The effect of pretreatment of geranylgeranylacetone (GGA), an inducer of heat shock protein (HSP) 70, on responses in sleep and core body temperature (Tcore) against sleep deprivation (SD) was examined in rats. After 3 days of GGA or vehicle injection, a 6-h period of SD was performed. During the recovery period, both rapid-eye movement (REM) and non-REM (NREM) sleep were increased in both GGA- and vehicle-injected rats. However, in GGA-injected rats, REM-sleep rebound was significantly suppressed, while NREM-sleep rebound remained unaffected. In addition, the increase of Tcore caused by SD was also attenuated in GGA-injected rats. In the hippocampus, both SD and the GGA pretreatment induced an increase in the expression of HSP70 mRNA, indicating that the SD functions as a stress for hippocampal neurons and that the GGA induces HSP70 expression. The findings suggest that pretreatment with GGA suppresses REM sleep rebound and the response of Tcore against SD.

UI MeSH Term Description Entries
D008297 Male Males
D004224 Diterpenes Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate. Diterpene,Diterpenes, Cembrane,Diterpenes, Labdane,Diterpenoid,Labdane Diterpene,Norditerpene,Norditerpenes,Norditerpenoid,Cembranes,Diterpenoids,Labdanes,Norditerpenoids,Cembrane Diterpenes,Diterpene, Labdane,Labdane Diterpenes
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012333 RNA, Messenger RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm. Messenger RNA,Messenger RNA, Polyadenylated,Poly(A) Tail,Poly(A)+ RNA,Poly(A)+ mRNA,RNA, Messenger, Polyadenylated,RNA, Polyadenylated,mRNA,mRNA, Non-Polyadenylated,mRNA, Polyadenylated,Non-Polyadenylated mRNA,Poly(A) RNA,Polyadenylated mRNA,Non Polyadenylated mRNA,Polyadenylated Messenger RNA,Polyadenylated RNA,RNA, Polyadenylated Messenger,mRNA, Non Polyadenylated
D012892 Sleep Deprivation The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder. Inadequate Sleep,Insufficient Sleep,Insufficient Sleep Syndrome,REM Sleep Deprivation,Sleep Debt,Sleep Fragmentation,Sleep Insufficiency,Deprivation, REM Sleep,Deprivation, Sleep,Fragmentation, Sleep,Insufficiencies, Sleep,Insufficiency, Sleep,Insufficient Sleep Syndromes,Sleep Deprivation, REM,Sleep Insufficiencies,Sleep, Inadequate,Sleep, Insufficient,Syndrome, Insufficient Sleep
D012895 Sleep, REM A stage of sleep characterized by rapid movements of the eye and low voltage fast pattern EEG. It is usually associated with dreaming. Fast-Wave Sleep,Paradoxical Sleep,Rapid Eye Movements,Rhombencephalic Sleep,Sleep, Fast-Wave,REM Sleep,Eye Movement, Rapid,Eye Movements, Rapid,Fast Wave Sleep,Movement, Rapid Eye,Movements, Rapid Eye,Rapid Eye Movement,Sleep, Fast Wave,Sleep, Paradoxical,Sleep, Rhombencephalic
D017208 Rats, Wistar A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain. Wistar Rat,Rat, Wistar,Wistar Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D018840 HSP70 Heat-Shock Proteins A class of MOLECULAR CHAPERONES found in both prokaryotes and in several compartments of eukaryotic cells. These proteins can interact with polypeptides during a variety of assembly processes in such a way as to prevent the formation of nonfunctional structures. Heat-Shock Proteins 70,Heat Shock 70 kDa Protein,Heat-Shock Protein 70,HSP70 Heat Shock Proteins,Heat Shock Protein 70,Heat Shock Proteins 70,Heat-Shock Proteins, HSP70

Related Publications

Tadashi Wada, and Hiroyoshi Sei, and Kenji Kusumoto, and Kazuyoshi Kitaoka, and Sachiko Chikahisa, and Kazuhito Rokutan, and Yusuke Morita
August 1990, Electroencephalography and clinical neurophysiology,
Tadashi Wada, and Hiroyoshi Sei, and Kenji Kusumoto, and Kazuyoshi Kitaoka, and Sachiko Chikahisa, and Kazuhito Rokutan, and Yusuke Morita
August 1997, The American journal of physiology,
Tadashi Wada, and Hiroyoshi Sei, and Kenji Kusumoto, and Kazuyoshi Kitaoka, and Sachiko Chikahisa, and Kazuhito Rokutan, and Yusuke Morita
November 2000, Transplantation proceedings,
Tadashi Wada, and Hiroyoshi Sei, and Kenji Kusumoto, and Kazuyoshi Kitaoka, and Sachiko Chikahisa, and Kazuhito Rokutan, and Yusuke Morita
December 1993, Brain research,
Tadashi Wada, and Hiroyoshi Sei, and Kenji Kusumoto, and Kazuyoshi Kitaoka, and Sachiko Chikahisa, and Kazuhito Rokutan, and Yusuke Morita
February 2010, Sleep medicine,
Tadashi Wada, and Hiroyoshi Sei, and Kenji Kusumoto, and Kazuyoshi Kitaoka, and Sachiko Chikahisa, and Kazuhito Rokutan, and Yusuke Morita
June 1975, Biological psychiatry,
Tadashi Wada, and Hiroyoshi Sei, and Kenji Kusumoto, and Kazuyoshi Kitaoka, and Sachiko Chikahisa, and Kazuhito Rokutan, and Yusuke Morita
August 2013, Psychopharmacology,
Tadashi Wada, and Hiroyoshi Sei, and Kenji Kusumoto, and Kazuyoshi Kitaoka, and Sachiko Chikahisa, and Kazuhito Rokutan, and Yusuke Morita
October 2011, Neurochemistry international,
Tadashi Wada, and Hiroyoshi Sei, and Kenji Kusumoto, and Kazuyoshi Kitaoka, and Sachiko Chikahisa, and Kazuhito Rokutan, and Yusuke Morita
August 1983, Physiology & behavior,
Tadashi Wada, and Hiroyoshi Sei, and Kenji Kusumoto, and Kazuyoshi Kitaoka, and Sachiko Chikahisa, and Kazuhito Rokutan, and Yusuke Morita
January 1987, Endocrinologie,
Copied contents to your clipboard!