Fear conditioning performance and NMDA receptor subtypes: NR2A differential expression in the striatum. 2006

Eduardo E Schenberg, and Tatiana L Ferreira, and Larissa Z P Figueredo, and Débora C Hipólide, and José N Nobrega, and Maria G M Oliveira
Departamento de Psicobiologia, Universidade Federal de São Paulo, UNIFESP, SP, Brazil.

While considerable evidence implicates NMDA receptors in the hippocampus in contextual fear conditioning, the role of other brain regions is less well understood. To further investigate this issue, rats were subjected to a contextual fear conditioning task and then classified as high or low responders according to performance. Density of NMDA receptors was evaluated using [3H]MK-801 autoradiography in 52 brain areas and expression of NR2A and NR2B subunits was studied with in situ hybridization in the same brains. Results revealed no differences between high- and low-performance rats in NMDA receptor binding in any of the brain areas studied. Similarly, NR2B subunit expression was also not different between groups. However, NR2A expression was significantly higher in the caudate-putamen of low-performance rats. These results suggest that NMDA receptors in the caudate-putamen may also be involved in contextual fear conditioning performance.

UI MeSH Term Description Entries
D008297 Male Males
D011699 Putamen The largest and most lateral of the BASAL GANGLIA lying between the lateral medullary lamina of the GLOBUS PALLIDUS and the EXTERNAL CAPSULE. It is part of the neostriatum and forms part of the LENTIFORM NUCLEUS along with the GLOBUS PALLIDUS. Nucleus Putamen,Nucleus Putamens,Putamen, Nucleus,Putamens,Putamens, Nucleus
D002421 Caudate Nucleus Elongated gray mass of the neostriatum located adjacent to the lateral ventricle of the brain. Caudatus,Nucleus Caudatus,Caudatus, Nucleus,Nucleus, Caudate
D003213 Conditioning, Psychological Simple form of learning involving the formation, strengthening, or weakening of an association between a stimulus and a response. Conditioning, Psychology,Psychological Conditioning,Social Learning Theory,Social Learning Theories,Theory, Social Learning
D003342 Corpus Striatum Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE. Lenticular Nucleus,Lentiform Nucleus,Lentiform Nuclei,Nucleus Lentiformis,Lentiformis, Nucleus,Nuclei, Lentiform,Nucleus, Lenticular,Nucleus, Lentiform,Striatum, Corpus
D005239 Fear The affective response to an actual current external danger which subsides with the elimination of the threatening condition. Threat Cues,Threat Sensitivity,Cue, Threat,Fears,Sensitivity, Threat,Threat Cue,Threat Sensitivities
D006624 Hippocampus A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation. Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D000679 Amygdala Almond-shaped group of basal nuclei anterior to the INFERIOR HORN OF THE LATERAL VENTRICLE of the TEMPORAL LOBE. The amygdala is part of the limbic system. Amygdaloid Body,Amygdaloid Nuclear Complex,Amygdaloid Nucleus,Archistriatum,Corpus Amygdaloideum,Intercalated Amygdaloid Nuclei,Massa Intercalata,Nucleus Amygdalae,Amygdalae, Nucleus,Amygdaloid Bodies,Amygdaloid Nuclear Complices,Amygdaloid Nuclei, Intercalated,Amygdaloid Nucleus, Intercalated,Amygdaloideum, Corpus,Amygdaloideums, Corpus,Archistriatums,Complex, Amygdaloid Nuclear,Complices, Amygdaloid Nuclear,Corpus Amygdaloideums,Intercalata, Massa,Intercalatas, Massa,Intercalated Amygdaloid Nucleus,Massa Intercalatas,Nuclear Complex, Amygdaloid,Nuclear Complices, Amygdaloid,Nuclei, Intercalated Amygdaloid,Nucleus, Amygdaloid,Nucleus, Intercalated Amygdaloid
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012333 RNA, Messenger RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm. Messenger RNA,Messenger RNA, Polyadenylated,Poly(A) Tail,Poly(A)+ RNA,Poly(A)+ mRNA,RNA, Messenger, Polyadenylated,RNA, Polyadenylated,mRNA,mRNA, Non-Polyadenylated,mRNA, Polyadenylated,Non-Polyadenylated mRNA,Poly(A) RNA,Polyadenylated mRNA,Non Polyadenylated mRNA,Polyadenylated Messenger RNA,Polyadenylated RNA,RNA, Polyadenylated Messenger,mRNA, Non Polyadenylated

Related Publications

Eduardo E Schenberg, and Tatiana L Ferreira, and Larissa Z P Figueredo, and Débora C Hipólide, and José N Nobrega, and Maria G M Oliveira
August 2007, Neuropharmacology,
Eduardo E Schenberg, and Tatiana L Ferreira, and Larissa Z P Figueredo, and Débora C Hipólide, and José N Nobrega, and Maria G M Oliveira
February 2008, Learning & memory (Cold Spring Harbor, N.Y.),
Eduardo E Schenberg, and Tatiana L Ferreira, and Larissa Z P Figueredo, and Débora C Hipólide, and José N Nobrega, and Maria G M Oliveira
April 2010, Journal of neurophysiology,
Eduardo E Schenberg, and Tatiana L Ferreira, and Larissa Z P Figueredo, and Débora C Hipólide, and José N Nobrega, and Maria G M Oliveira
December 1996, Brain research,
Eduardo E Schenberg, and Tatiana L Ferreira, and Larissa Z P Figueredo, and Débora C Hipólide, and José N Nobrega, and Maria G M Oliveira
April 2004, Journal of neurochemistry,
Eduardo E Schenberg, and Tatiana L Ferreira, and Larissa Z P Figueredo, and Débora C Hipólide, and José N Nobrega, and Maria G M Oliveira
May 2013, Learning & memory (Cold Spring Harbor, N.Y.),
Eduardo E Schenberg, and Tatiana L Ferreira, and Larissa Z P Figueredo, and Débora C Hipólide, and José N Nobrega, and Maria G M Oliveira
April 1997, The Journal of neuroscience : the official journal of the Society for Neuroscience,
Eduardo E Schenberg, and Tatiana L Ferreira, and Larissa Z P Figueredo, and Débora C Hipólide, and José N Nobrega, and Maria G M Oliveira
October 2003, Brain research,
Eduardo E Schenberg, and Tatiana L Ferreira, and Larissa Z P Figueredo, and Débora C Hipólide, and José N Nobrega, and Maria G M Oliveira
October 1994, The Journal of comparative neurology,
Eduardo E Schenberg, and Tatiana L Ferreira, and Larissa Z P Figueredo, and Débora C Hipólide, and José N Nobrega, and Maria G M Oliveira
July 2005, The European journal of neuroscience,
Copied contents to your clipboard!