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1. To determine whether a persistent release of creatine kinase from the myocardium occurs in patients with hypertrophic cardiomyopathy, the activities of serum creatine kinase MM isoforms were measured in 22 patients with hypertrophic cardiomyopathy and in 14 normal control subjects. 2. Serum creatine kinase MB activity was significantly higher in patients with hypertrophic cardiomyopathy (7.8 +/- 3.8 i.u./l) than in normal control subjects (0.4 +/- 0.8 i.u./l; P less than 0.01). 3. Serum MMa, MMb and MMc activities in patients with hypertrophic cardiomyopathy were 19.4 +/- 4.1%, 26.7 +/- 2.5% and 33.5 +/- 7.0% of the total creatine kinase MM activity, respectively. These values for each isoform were significantly different from those in normal control subjects (11.3 +/- 3.0%, 21.5 +/- 4.4% and 40.7 +/- 7.0%, respectively). The MMa/MMc activity ratio was significantly higher in patients with hypertrophic cardiomyopathy (0.61 +/- 0.25) than in normal control subjects (0.30 +/- 0.10; P less than 0.01). 4. Our results indicate that a small amount of the myocardial tissue isoform of creatine kinase MM (MMa) is constantly released in many patients with hypertrophic cardiomyopathy.
M Hamada, and
T Ohtani, and
M Sekiya, and
Y Fujiwara, and
T Sumimoto, and
K Hiwada, and
S Morita, and
H Tsukada
June 1988,
Clinical chemistry,
M Hamada, and
T Ohtani, and
M Sekiya, and
Y Fujiwara, and
T Sumimoto, and
K Hiwada, and
S Morita, and
H Tsukada
April 1997,
Japanese circulation journal,
M Hamada, and
T Ohtani, and
M Sekiya, and
Y Fujiwara, and
T Sumimoto, and
K Hiwada, and
S Morita, and
H Tsukada
June 1993,
Chinese medical journal,
M Hamada, and
T Ohtani, and
M Sekiya, and
Y Fujiwara, and
T Sumimoto, and
K Hiwada, and
S Morita, and
H Tsukada
June 1987,
Cardiovascular research,
M Hamada, and
T Ohtani, and
M Sekiya, and
Y Fujiwara, and
T Sumimoto, and
K Hiwada, and
S Morita, and
H Tsukada
August 1988,
Clinical biochemistry,
M Hamada, and
T Ohtani, and
M Sekiya, and
Y Fujiwara, and
T Sumimoto, and
K Hiwada, and
S Morita, and
H Tsukada
January 1993,
American heart journal,
M Hamada, and
T Ohtani, and
M Sekiya, and
Y Fujiwara, and
T Sumimoto, and
K Hiwada, and
S Morita, and
H Tsukada
September 1994,
Clinica chimica acta; international journal of clinical chemistry,
M Hamada, and
T Ohtani, and
M Sekiya, and
Y Fujiwara, and
T Sumimoto, and
K Hiwada, and
S Morita, and
H Tsukada
January 1998,
Anales de medicina interna (Madrid, Spain : 1984),
M Hamada, and
T Ohtani, and
M Sekiya, and
Y Fujiwara, and
T Sumimoto, and
K Hiwada, and
S Morita, and
H Tsukada
December 1990,
Zhonghua xin xue guan bing za zhi,
M Hamada, and
T Ohtani, and
M Sekiya, and
Y Fujiwara, and
T Sumimoto, and
K Hiwada, and
S Morita, and
H Tsukada
December 1985,
The Journal of biological chemistry,
