BIOMAT Database Logo BIOMAT Database Logo

t(14;18)(q32;q21) involving IGH and MALT1 is uncommon in cutaneous MALT lymphomas and primary cutaneous diffuse large B-cell lymphomas. 2006

Nicholas T Wongchaowart, and Bong Kim, and Eric D Hsi, and Steven H Swerdlow, and Raymond R Tubbs, and James R Cook
Department of Clinical Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

BACKGROUND t(14;18)(q32;q21) involving IGH and MALT1 has been demonstrated in cutaneous MALT lymphomas and in one case of primary cutaneous diffuse large B-cell lymphoma (DLBCL). However, the incidence of IGH/MALT1 translocations in these forms of cutaneous lymphoma remains unclear. METHODS We performed paraffin section interphase fluorescence in situ hybridization (FISH) analysis using MALT1 and IGH break-apart probes on 16 cutaneous MALT lymphomas and 16 primary cutaneous DLBCL in order to assess the frequency of IGH/MALT1 translocations and to screen for other potential translocations involving the IGH or MALT1 loci. RESULTS Translocations involving MALT1 were not detected in any of 16 cutaneous MALT lymphomas or 16 primary cutaneous DLBCL. Of the 12 MALT lymphomas that could be analyzed for an IGH translocation, all were negative. In contrast, four of the 13 cases (31%) of primary cutaneous DLBCL that could be analyzed for translocations involving IGH were positive. Subsequent FISH analysis demonstrated one of these to be an IGH/BCL2 translocation and one to be a CMYC/IGH translocation, while the translocation partners in the remaining two cases are currently unidentified. CONCLUSIONS This study demonstrates that translocations involving MALT1, including IGH/MALT1, are uncommon in cutaneous MALT lymphomas and primary cutaneous DLBCL. Other translocations involving IGH also are not involved in the pathogenesis of at least most cutaneous MALT lymphomas. In contrast, primary cutaneous DLBCL may contain one of several IGH translocations in a minority of cases.

UI MeSH Term Description Entries
D007143 Immunoglobulin Heavy Chains The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa. Immunoglobulins, Heavy-Chain,Heavy-Chain Immunoglobulins,Ig Heavy Chains,Immunoglobulin Heavy Chain,Immunoglobulin Heavy Chain Subgroup VH-I,Immunoglobulin Heavy Chain Subgroup VH-III,Heavy Chain Immunoglobulins,Heavy Chain, Immunoglobulin,Heavy Chains, Ig,Heavy Chains, Immunoglobulin,Immunoglobulin Heavy Chain Subgroup VH I,Immunoglobulin Heavy Chain Subgroup VH III,Immunoglobulins, Heavy Chain
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009363 Neoplasm Proteins Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm. Proteins, Neoplasm
D002883 Chromosomes, Human, Pair 14 A specific pair of GROUP D CHROMOSOMES of the human chromosome classification. Chromosome 14
D002887 Chromosomes, Human, Pair 18 A specific pair of GROUP E CHROMOSOMES of the human chromosome classification. Chromosome 18
D003937 Diagnosis, Differential Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures. Diagnoses, Differential,Differential Diagnoses,Differential Diagnosis
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000074884 Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein A caspase-like cysteine endopeptidase that also exhibits ubiquitin ligase activity. It contains an N-terminal DEATH DOMAIN, two IMMUNOGLOBULIN-LIKE DOMAINS, and localizes to the perinuclear region of MONOCYTES, where it functions in activation of NF-KAPPA B; it also binds to and activates TRAF6. Chromosomal translocations involving the MALT1 and BIRC2 genes are associated with MALT LYMPHOMA, and mutations in the MALT1 gene are associated with Type 12 IMMUNODEFICIENCY SYNDROMES. MALT-1 Protein,MALT1 Paracaspase,MALT1 Protein,Paracaspase,MALT 1 Protein,Mucosa Associated Lymphoid Tissue Lymphoma Translocation 1 Protein,Paracaspase, MALT1

Related Publications

Nicholas T Wongchaowart, and Bong Kim, and Eric D Hsi, and Steven H Swerdlow, and Raymond R Tubbs, and James R Cook
T(14;18)(q32;q21) involving MALT1 and IGH genes in an extranodal diffuse large B-cell lymphoma.
November 2003, Human pathology,
Nicholas T Wongchaowart, and Bong Kim, and Eric D Hsi, and Steven H Swerdlow, and Raymond R Tubbs, and James R Cook
T(14;18)(q32;q21) involving MALT1 and IGH genes occurs in extranodal diffuse large B-cell lymphomas of the breast and testis.
March 2013, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc,
Nicholas T Wongchaowart, and Bong Kim, and Eric D Hsi, and Steven H Swerdlow, and Raymond R Tubbs, and James R Cook
T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma.
March 2003, Blood,
Nicholas T Wongchaowart, and Bong Kim, and Eric D Hsi, and Steven H Swerdlow, and Raymond R Tubbs, and James R Cook
The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas is a CpG-type translocation, but the t(11;18)(q21;q21)/API2-MALT1 translocation in MALT lymphomas is not.
April 2010, Blood,
Nicholas T Wongchaowart, and Bong Kim, and Eric D Hsi, and Steven H Swerdlow, and Raymond R Tubbs, and James R Cook
Translocations t(11;18)(q21;q21) and t(14;18)(q32;q21) are the main chromosomal abnormalities involving MLT/MALT1 in MALT lymphomas.
November 2003, Leukemia,
Nicholas T Wongchaowart, and Bong Kim, and Eric D Hsi, and Steven H Swerdlow, and Raymond R Tubbs, and James R Cook
MALT lymphoma with t(14;18)(q32;q21)/IGH-MALT1 is characterized by strong cytoplasmic MALT1 and BCL10 expression.
February 2005, The Journal of pathology,
Nicholas T Wongchaowart, and Bong Kim, and Eric D Hsi, and Steven H Swerdlow, and Raymond R Tubbs, and James R Cook
Waldenstrom's macroglobulinemia-like B cell lymphoma with MYD88 L265P mutation and t(14;18)(q32;q21) involving IGH-MALT1.
January 2023, Leukemia research reports,
Nicholas T Wongchaowart, and Bong Kim, and Eric D Hsi, and Steven H Swerdlow, and Raymond R Tubbs, and James R Cook
Primary cutaneous marginal zone B-cell lymphoma may exhibit both the t(14;18)(q32;q21) IGH/BCL2 and the t(14;18)(q32;q21) IGH/MALT1 translocation: an indicator for clonal transformation towards higher-grade B-cell lymphoma?
June 2007, The American Journal of dermatopathology,
Nicholas T Wongchaowart, and Bong Kim, and Eric D Hsi, and Steven H Swerdlow, and Raymond R Tubbs, and James R Cook
Novel identification of t(14;18)(q32;q21)/IGH::MALT1 in chronic lymphocytic leukaemia.
February 2024, British journal of haematology,
Nicholas T Wongchaowart, and Bong Kim, and Eric D Hsi, and Steven H Swerdlow, and Raymond R Tubbs, and James R Cook
The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas contains templated nucleotide insertions and a major breakpoint region similar to follicular and mantle cell lymphoma.
March 2010, Blood,
Copied contents to your clipboard!