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The anxiogenic activity of N-methyl-beta-carboline-3-carboxamide (FG 7142) is sometimes difficult to observe in rats. As the open field has recently been applied successfully to test the anxiogenic potential of n-butyl-beta-carboline-3-carboxylate (beta-CCB) in mice, a comparable experiment was performed with FG 7142 (1, 5, 10, 30 mg/kg i.p.) in rats. In contrast to the inhibitory effects measured with beta-CCB, FG 7142 significantly increased the ambulation and rearing scores and induced aggressivity in some animals. A differential sensitivity of mice and rats to beta-carbolines, predominant analeptic properties of FG 7142, and differences in the types of anxiety induced are proposed to account for this discrepancy.
J Bruhwyler, and
E Chleide, and
G Houbeau, and
M Mercier
October 1993,
Physiology & behavior,
J Bruhwyler, and
E Chleide, and
G Houbeau, and
M Mercier
December 1985,
Biulleten' eksperimental'noi biologii i meditsiny,
J Bruhwyler, and
E Chleide, and
G Houbeau, and
M Mercier
February 1998,
Physiology & behavior,
J Bruhwyler, and
E Chleide, and
G Houbeau, and
M Mercier
January 1989,
Psychopharmacology,
J Bruhwyler, and
E Chleide, and
G Houbeau, and
M Mercier
December 1985,
Neuroscience letters,
J Bruhwyler, and
E Chleide, and
G Houbeau, and
M Mercier
April 1989,
European journal of pharmacology,
J Bruhwyler, and
E Chleide, and
G Houbeau, and
M Mercier
October 1984,
Pharmacology, biochemistry, and behavior,
J Bruhwyler, and
E Chleide, and
G Houbeau, and
M Mercier
January 1983,
Lancet (London, England),
J Bruhwyler, and
E Chleide, and
G Houbeau, and
M Mercier
July 1983,
Lancet (London, England),
J Bruhwyler, and
E Chleide, and
G Houbeau, and
M Mercier
September 1987,
Brain research bulletin,
