Hyperhomocysteinemia is a significant risk factor for silent cerebral infarction in patients with chronic renal failure undergoing hemodialysis. 2006

Futoshi Anan, and Naohiko Takahashi, and Tsuyoshi Shimomura, and Muneharu Imagawa, and Kunio Yufu, and Tomoko Nawata, and Mikiko Nakagawa, and Hidetoshi Yonemochi, and Nobuoki Eshima, and Tetsunori Saikawa, and Hironobu Yoshimatsu
Department of Cardiology, Oita Red Cross Hospital, and Department of Cardiovascular Science, School of Medicine, Oita University, Oita 879-5593, Japan. anan-f@med.oita-u.ac.jp

In patients with chronic renal failure undergoing hemodialysis (HD), the presence of silent cerebral infarction (SCI) is associated with high mortality. Plasma total homocysteine (tHcy), which increases with renal dysfunction, has been flagged as a novel predictor for cerebrovascular events. We tested the hypothesis that the presence of SCI correlates with tHcy in HD patients. Based on brain magnetic resonance imaging findings, 44 patients undergoing HD were divided into a with-SCI group (61+/-9 years [mean+/-SD]; n=24) and a without-SCI group (60+/-8 years, n=20), in whom 24-hour ambulatory blood pressure monitoring was performed. The number of patients with diabetes or hypertension was not different between the 2 groups. We made the following observations: (1) the percentage of smokers was higher in the with-SCI group than in the without-SCI group (P<.05); (2) plasma levels of high-density lipoprotein cholesterol were lower and tHcy was higher in the with-SCI group than in the without-SCI group (P<.05 and P<.0001, respectively); (3) and systolic ambulatory blood pressure and mean heart rate during nighttime were higher in the with-SCI group than in the without-SCI group (P<.05). Multivariate logistic analysis identified hyperhomocysteinemia as an independent and significant risk factor for SCI (odds ratio, 1.22; 95% CI, 1.10-1.36; P<.01). Our findings indicate that plasma tHcy may be a novel useful predictor for SCI in patients with chronic renal failure undergoing HD.

UI MeSH Term Description Entries
D007676 Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. ESRD,End-Stage Renal Disease,Renal Disease, End-Stage,Renal Failure, Chronic,Renal Failure, End-Stage,Chronic Kidney Failure,End-Stage Kidney Disease,Chronic Renal Failure,Disease, End-Stage Kidney,Disease, End-Stage Renal,End Stage Kidney Disease,End Stage Renal Disease,End-Stage Renal Failure,Kidney Disease, End-Stage,Renal Disease, End Stage,Renal Failure, End Stage
D008076 Cholesterol, HDL Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol. High Density Lipoprotein Cholesterol,Cholesterol, HDL2,Cholesterol, HDL3,HDL Cholesterol,HDL(2) Cholesterol,HDL(3) Cholesterol,HDL2 Cholesterol,HDL3 Cholesterol,alpha-Lipoprotein Cholesterol,Cholesterol, alpha-Lipoprotein,alpha Lipoprotein Cholesterol
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D002544 Cerebral Infarction The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction). Anterior Choroidal Artery Infarction,Cerebral Infarct,Infarction, Cerebral,Posterior Choroidal Artery Infarction,Subcortical Infarction,Cerebral Infarction, Left Hemisphere,Cerebral Infarction, Right Hemisphere,Cerebral, Left Hemisphere, Infarction,Cerebral, Right Hemisphere, Infarction,Infarction, Cerebral, Left Hemisphere,Infarction, Cerebral, Right Hemisphere,Infarction, Left Hemisphere, Cerebral,Infarction, Right Hemisphere, Cerebral,Left Hemisphere, Cerebral Infarction,Left Hemisphere, Infarction, Cerebral,Right Hemisphere, Cerebral Infarction,Right Hemisphere, Infarction, Cerebral,Cerebral Infarctions,Cerebral Infarcts,Infarct, Cerebral,Infarction, Subcortical,Infarctions, Cerebral,Infarctions, Subcortical,Infarcts, Cerebral,Subcortical Infarctions
D005260 Female Females
D006339 Heart Rate The number of times the HEART VENTRICLES contract per unit of time, usually per minute. Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006435 Renal Dialysis Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION. Dialysis, Extracorporeal,Dialysis, Renal,Extracorporeal Dialysis,Hemodialysis,Dialyses, Extracorporeal,Dialyses, Renal,Extracorporeal Dialyses,Hemodialyses,Renal Dialyses
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Futoshi Anan, and Naohiko Takahashi, and Tsuyoshi Shimomura, and Muneharu Imagawa, and Kunio Yufu, and Tomoko Nawata, and Mikiko Nakagawa, and Hidetoshi Yonemochi, and Nobuoki Eshima, and Tetsunori Saikawa, and Hironobu Yoshimatsu
January 2008, Metabolism: clinical and experimental,
Futoshi Anan, and Naohiko Takahashi, and Tsuyoshi Shimomura, and Muneharu Imagawa, and Kunio Yufu, and Tomoko Nawata, and Mikiko Nakagawa, and Hidetoshi Yonemochi, and Nobuoki Eshima, and Tetsunori Saikawa, and Hironobu Yoshimatsu
January 2002, Electromyography and clinical neurophysiology,
Futoshi Anan, and Naohiko Takahashi, and Tsuyoshi Shimomura, and Muneharu Imagawa, and Kunio Yufu, and Tomoko Nawata, and Mikiko Nakagawa, and Hidetoshi Yonemochi, and Nobuoki Eshima, and Tetsunori Saikawa, and Hironobu Yoshimatsu
January 2006, Nature clinical practice. Nephrology,
Futoshi Anan, and Naohiko Takahashi, and Tsuyoshi Shimomura, and Muneharu Imagawa, and Kunio Yufu, and Tomoko Nawata, and Mikiko Nakagawa, and Hidetoshi Yonemochi, and Nobuoki Eshima, and Tetsunori Saikawa, and Hironobu Yoshimatsu
October 2008, Metabolism: clinical and experimental,
Futoshi Anan, and Naohiko Takahashi, and Tsuyoshi Shimomura, and Muneharu Imagawa, and Kunio Yufu, and Tomoko Nawata, and Mikiko Nakagawa, and Hidetoshi Yonemochi, and Nobuoki Eshima, and Tetsunori Saikawa, and Hironobu Yoshimatsu
October 2000, Polskie Archiwum Medycyny Wewnetrznej,
Futoshi Anan, and Naohiko Takahashi, and Tsuyoshi Shimomura, and Muneharu Imagawa, and Kunio Yufu, and Tomoko Nawata, and Mikiko Nakagawa, and Hidetoshi Yonemochi, and Nobuoki Eshima, and Tetsunori Saikawa, and Hironobu Yoshimatsu
July 1995, Nutrition reviews,
Futoshi Anan, and Naohiko Takahashi, and Tsuyoshi Shimomura, and Muneharu Imagawa, and Kunio Yufu, and Tomoko Nawata, and Mikiko Nakagawa, and Hidetoshi Yonemochi, and Nobuoki Eshima, and Tetsunori Saikawa, and Hironobu Yoshimatsu
January 2003, American journal of nephrology,
Futoshi Anan, and Naohiko Takahashi, and Tsuyoshi Shimomura, and Muneharu Imagawa, and Kunio Yufu, and Tomoko Nawata, and Mikiko Nakagawa, and Hidetoshi Yonemochi, and Nobuoki Eshima, and Tetsunori Saikawa, and Hironobu Yoshimatsu
January 2005, Medicina,
Futoshi Anan, and Naohiko Takahashi, and Tsuyoshi Shimomura, and Muneharu Imagawa, and Kunio Yufu, and Tomoko Nawata, and Mikiko Nakagawa, and Hidetoshi Yonemochi, and Nobuoki Eshima, and Tetsunori Saikawa, and Hironobu Yoshimatsu
January 1993, Presse medicale (Paris, France : 1983),
Futoshi Anan, and Naohiko Takahashi, and Tsuyoshi Shimomura, and Muneharu Imagawa, and Kunio Yufu, and Tomoko Nawata, and Mikiko Nakagawa, and Hidetoshi Yonemochi, and Nobuoki Eshima, and Tetsunori Saikawa, and Hironobu Yoshimatsu
December 2003, Neurology,
Copied contents to your clipboard!